Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients
Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients
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DOI：
10.1016/j.ijid.2015.10.021
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发表时间：
2016-01-01
影响因子：
8.4
通讯作者：
Wang, Fu-Sheng
中科院分区：
文献类型：
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作者：
Li, Jin;Duan, Hui-Juan;Wang, Fu-Sheng
背景：2014年10月至2015年3月，中国医疗队在塞拉利昂救治埃博拉病毒病（EVD）患者，共收治疑似患者693例，其中确诊患者288例。方法：对288例确诊患者进行回顾性研究。分析并比较不同组间的临床症状、表现和血清病毒载量的死亡率和生存时间。结果：在288例确诊的EVD患者中（男性149例，女性139例，中位年龄28岁，中位对数病毒载量6.68），死亡98例，康复36例，失访154例。常见症状为发热（77.78%）、乏力（64.93%）、腹痛（64.58%）、头痛（62.85%）、腹泻（61.81%）。与年龄 < 18 岁的患者相比，年龄超过 40 岁的患者死亡概率更高（比值比 2.855，p = 0.044）。病毒载量>10(6)拷贝/ml的患者比病毒载量低的患者病死率更高
Background: A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended to 693 suspected patients, of whom 288 had confirmed disease.Methods: A retrospective study was conducted of the 288 patients with confirmed disease. Clinical symptoms, manifestations, and serum viral load were analyzed and compared among the different groups for mortality and survival time.Results: Among the 288 confirmed EVD patients (149 male and 139 female, median age 28 years, and median log viral load 6.68), 98 died, 36 recovered, and 154 were lost to follow-up. Common symptoms were fever (77.78%), fatigue (64.93%), abdominal pain (64.58%), headache (62.85%), and diarrhea (61.81%). Compared to patients aged < 18 years, those who were older than 40 years had a higher probability of death (odds ratio 2.855, p = 0.044). Patients with a viral load of >10(6) copies/ml had a higher case fatality rate than those with