Aberrant Methylation of Multiple Genes in Gastric Carcinomas
Aberrant Methylation of Multiple Genes in Gastric Carcinomas
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DOI：
10.1177/1066896907302117
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发表时间：
2007-07
影响因子：
1.2
通讯作者：
Ying-fang Zhao;Yun-gang Zhang;X. Tian;Juan Du;Jie Zheng
中科院分区：
文献类型：
--
作者：
Ying-fang Zhao;Yun-gang Zhang;X. Tian;Juan Du;Jie Zheng
In this study, we examined aberrant methylation of the E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT genes by the methylation-specific polymerase chain reaction method in 101 gastric carcinomas. Hypermethylation was detected in E-cadherin, estrogen receptor, RB1, p16, p14, p15, and MGMT at the rates of 27.7%, 44.6%, 44.6%, 30.7%, 19.2%, 7.7%, and 6.9%, respectively. A total of 82.2% cases had methylation in at least 1 of these genes, and 44.6% had methylation in 2 or more of these genes. Methylation of RB1 was associated with absence of lymph node metastasis. Methylation of estrogen receptor was associated with age and tumor location. Methylation of E-cadherin coincided with methylation of p16 or estrogen receptor. Moreover, loss of p16 protein was strongly associated with its gene methylation. This study indicates that aberrant methylation of multiple genes is involved in gastric carcinogenesis.
