Multiple gates on working memory.
Multiple gates on working memory.
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DOI：
10.1016/j.cobeha.2014.08.001
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发表时间：
2015-02-01
影响因子：
5
通讯作者：
Badre D
中科院分区：
文献类型：
--
作者：
Chatham CH;Badre D
行动的背景可能只是短暂地可见、可及且相关。皮质 - 基底神经节（BG）回路通过允许正确的运动计划在正确的时间驱动行动来满足这些需求，这是通过基底神经节对运动表征的介导门控实现的。一个长期存在的假设认为，这些相同的回路在更前端的大脑区域被复制，以支持认知表征的门控。现在关键的证据支持这样的预测：基底神经节可以作为工作记忆输入的门控，作为其输出的门控，以及作为重新分配因近期事件而变得无关的工作记忆表征的一种手段。这些发现验证了许多计算模型的关键原则，限定了仅关于循环皮质动力学的运动和认知模型，并为高级认知机制的研究确定了新的方向。
The contexts for action may be only transiently visible, accessible, and relevant. The corticobasal ganglia (BG) circuit addresses these demands by allowing the right motor plans to drive action at the right times, via a BG-mediated gate on motor representations. A long-standing hypothesis posits these same circuits are replicated in more rostral brain regions to support gating of cognitive representations. Key evidence now supports the prediction that BG can act as a gate on the input to working memory, as a gate on its output, and as a means of reallocating working memory representations rendered irrelevant by recent events. These discoveries validate key tenets of many computational models, circumscribe motor and cognitive models of recurrent cortical dynamics alone, and identify novel directions for research on the mechanisms of higher-level cognition.