A genetic study of the acute anxious response to carbon dioxide stimulation in man
A genetic study of the acute anxious response to carbon dioxide stimulation in man
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DOI：
10.1016/j.jpsychires.2006.12.002
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发表时间：
2007-12-01
影响因子：
4.8
通讯作者：
Tambs, Kristian
中科院分区：
文献类型：
--
作者：
Battaglia, Marco;Ogliari, Anna;Tambs, Kristian
患有恐慌症的人和他们的亲属经常对富含二氧化碳的气体混合物做出焦虑的反应。现有的数据不适合解开从常见的环境原因的家庭聚集CO2反应性的遗传，也不提供定量估计的来源的性状variation. Three一百四十六双胞胎对属于一般人群为基础的挪威NIPH心理健康研究进行自我评估的焦虑和DSM-IV恐慌症状吸入后的35%CO2-65%O-2的混合物。在样本的第75次和第90次反应中采用了两个阈值，以定义激发的恐慌发作并计算多相关联。方差分量估计的结构方程模型（SEM）。对于所有13个恐慌症状的总和的基础上的反应的定义，SEM不能区分共享的环境与遗传原因的家族相似性挑起攻击。对于基于整体焦虑或CO2后方差最高的症状（呼吸困难、头晕、心悸）总和的反应定义，最佳拟合模型表明加性遗传因素是家族内相似性的唯一原因。最佳拟合的遗传度估计值在0.42 - 0.57之间。遗传和特异质环境因素解释了高碳酸血症反应性的大部分个体差异。这种性状的家族内相似性在很大程度上是由遗传决定因素解释的。(c)2006爱思唯尔有限公司版权所有。
People with panic disorder-agoraphobia and their relatives often react anxiously to CO2-enriched gas mixtures. Available data are not suited to disentangle genetic from common environmental causes of familial aggregation Of CO2 reactivity, nor provide quantitative estimations of the sources of trait variation.Three-hundred-forty-six twin pairs belonging to the general population-based Norwegian NIPH Mental Health Study underwent self-assessments of anxiety and of DSM-IV panic symptoms after inhalation of a 35%CO2-65%O-2 mixture. Two thresholds were employed at sample's 75th and 90th percentiles of responses - to define provoked panic attacks and to calculate polychoric correlations. Variance components were estimated by structural equation modelling (SEM).For definitions of responses based on the sum of all 13 panic symptoms, SEM could not discriminate between shared environmental versus genetic causes of familial resemblance for provoked attacks. For definitions of responses based on global anxiety, or on the sums of those symptoms (dyspnea, dizziness, palpitations) with highest variance Post-CO2, the best-fitting models indicated additive genetic factors as the sole causes for within-family resemblance. Best-fit heritability estimates ranged from 0.42 to 0.57.Genetic and idiosyncratic environmental factors explain most of individual differences in reactivity to hypercapnia. Within-family similarities for this trait are largely explained by genetic determinants. (c) 2006 Elsevier Ltd. All rights reserved.