NICOTINE PATCH THERAPY FOR SMOKING CESSATION COMBINED WITH PHYSICIAN ADVICE AND NURSE FOLLOW-UP - ONE-YEAR OUTCOME AND PERCENTAGE OF NICOTINE REPLACEMENT
NICOTINE PATCH THERAPY FOR SMOKING CESSATION COMBINED WITH PHYSICIAN ADVICE AND NURSE FOLLOW-UP - ONE-YEAR OUTCOME AND PERCENTAGE OF NICOTINE REPLACEMENT
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DOI：
10.1001/jama.271.8.595
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发表时间：
1994-02-23
影响因子：
120.7
通讯作者：
LUNDBERG, TG
中科院分区：
文献类型：
--
作者：
HURT, RD;DALE, LC;LUNDBERG, TG
Objective.-To determine the efficacy of a 22-mg nicotine patch combined with the National Cancer Institute program for physician advice and nurse follow-up in providing withdrawal symptom relief, 1-year smoking cessation outcome, and percentage of nicotine replacement. Design.-Randomized, double-blind, placebo-controlled trial. Subjects.-Two-hundred forty healthy volunteers who were smoking at least 20 cigarettes per day. Interventions.-Based on the National Cancer Institute program, subjects received smoking cessation advice from a physician. Follow-up and relapse prevention were provided by a study nurse during individual counseling sessions. Subjects were randomly assigned to 8 weeks of a 22-mg nicotine or placebo patch. Main Outcome Measures.-Abstinence from smoking was verified by expired air carbon monoxide levels. Withdrawal symptoms were recorded during patch therapy, and the percentage of nicotine replacement was calculated by dividing serum nicotine and cotinine levels at week 8 of patch therapy by levels obtained while smoking. Results.-Higher smoking cessation rates were observed in the active nicotine patch group at 8 weeks (46.7% vs 20%) (P
