Transgenerational Metabolic Determinants of Fetal Birth Weight
Transgenerational Metabolic Determinants of Fetal Birth Weight
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DOI：
10.1055/s-0033-1345121
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发表时间：
2013-07-01
影响因子：
1.8
通讯作者：
Vassallo, J.
中科院分区：
文献类型：
--
作者：
Agius, R.;Savona-Ventura, C.;Vassallo, J.
背景资料：长期以来，出生体重较高的婴儿与从幼儿期开始并持续到成年的代谢综合征发病率增加有关。此类风险因素包括遗传倾向以及环境因素。其中，某些母体的人体测量特征，如肥胖或碳水化合物不耐受，改变了宫内环境的营养丰富，从而影响宫内发育。这种营养过剩的途径导致了“燃料介导的致畸作用”和肥胖环境的假设。目的：目的是确定3代人之间的关系，体重和出生体重，以确定是否遗传和/或营养的作用参与观察transmitt.Methods/Materials：该研究利用了2个临床数据库。第一组包括182名出生于1987年的妇女，她们在2004-2010年期间生了一个孩子[第二代]。总共有233名婴儿出生[第三代]。这进一步与1987年分娩过一个孩子的妇女的另一个数据库相关联[第一代]。登记了第2代和第3代的出生体重以及第1代和第2代的孕前体重指数（BMI），以及第1代人群中代谢综合征特征的发展。第一代人群根据BMI分为2组：BMI = 25 kg/m（2）（n = 106）。平均出生体重和孕前BMI的后代进行了比较，使用学生t检验。结果：有没有直接的代际之间的联系，第一代BMI和第三代出生体重。相反，出生体重与母亲BMI直接相关。此外，在这项研究中，我们还研究了第一代母亲是否存在代谢综合征。代谢综合征的存在或不存在并没有造成任何统计学上的显着差异，在出生体重的第2和第3 generation.Conclusions：这项研究支持以前的报告，环境因素起着关键作用，在确定胎儿出生体重。识别孕前BMI较高的妇女，并教育她们在怀孕前进行饮食调整以减轻体重，这将有助于减少对母亲和孩子的短期和长期不良后果。
Background: Infants born with a higher birth weight have long been associated with an increased incidence of developing the metabolic syndrome starting from early childhood and persisting into adult life. Such risk factors include genetic tendencies as well as environmental factors. Of these, certain maternal anthropometric characteristics such as obesity or carbohydrate intolerance alter the intrauterine environment to one of nutritional plenty, thus impacting on intrauterine development. This hypernutrition pathway has led to the hypothesis of 'fuel mediated teratogenesis' and an obesogenic environment.Aims: The aim was to identify a relationship across 3 generations relating to body weight and birth weight in order to identify whether a genetic and/or nutritional role are involved in the observed transmission.Methods/Materials: The study utilized 2 clinical databases. The first consisted of a cohort of 182 women born in 1987 and who delivered a child between 2004-2010 [2nd Generation]. A total of 233 infants were born [3rd Generation]. This was further linked to another database of women who had delivered a child in 1987 [1st Generation]. The birth weight of the 2nd and 3rd generations and the pre-pregnancy body mass index (BMI) of the 1st and 2nd generation were registered as was the development of features of the metabolic syndrome in the 1st generation population. The 1st generation population was subdivided into 2 groups based on the BMI: BMI = 25 kg/m(2) (n = 106). The mean birth weights and pre-pregnancy BMI of the subsequent generations were compared using the student t-test.Results: There was no direct transgenerational link between the first generation BMI and third generation birth weight. Rather, birth weight was directly linked to maternal BMI. Furthermore in this study we also studied the presence of metabolic syndrome in first generation mothers. The presence or absence of metabolic syndrome did not cause any statistically significant difference in the birth weight of 2nd and 3rd generations.Conclusions: This study supports previous reports that environmental factors play a key role in determining fetal birth weight. Identifying women with a higher pre-pregnancy BMI and educating them with regards to dietary modification in order to reduce body weight prior to pregnancy would contribute towards less adverse outcomes to the mother and her child in both the short and the long term.