Total homocysteine, diet, and lipid profiles in type 1 and type 2 diabetic and nondiabetic adolescents
Total homocysteine, diet, and lipid profiles in type 1 and type 2 diabetic and nondiabetic adolescents
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DOI：
10.1097/00005082-200601000-00010
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Reynolds, Robert D.
中科院分区：
文献类型：
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作者：
Faulkner, Melissa Spezia;Chao, Wei-Hsun;Reynolds, Robert D.
背景与研究目的：关于青少年I型糖尿病（DM）、2型DM或健康对照组之间总同型半胱氨酸（tHcy）、膳食能量和脂质等心血管危险因素的可能差异，现有研究有限。本研究的主要目的是比较1型糖尿病、2型糖尿病和健康非糖尿病对照青少年的膳食能量、叶酸、维生素B-6和B-12等常量营养素和微量营养素的摄入以及脂质和tHcy。主题和方法：合并2个数据集的次要分析包括以下青少年：50例1型DM，14例2型DM和53例对照。I型和2型糖尿病患者的平均年龄分别为15.2 ± 1.9岁和16.1 ± 1.9岁。对照组的平均年龄为16.5 ± 1.0岁。变量包括空腹tHcy和血脂，以及24小时膳食中大量营养素和微量营养素的回忆。糖尿病患者的血红蛋白A，。统计分析包括单因素方差分析、皮尔逊相关分析和逐步回归分析。结果与结论：1型糖尿病青少年的tHcy值最低（P <0.05），这反映了对这一人群的研究有限。血脂谱和膳食能量在3组之间没有显着差异。在1型糖尿病患者中，血红蛋白A（1c）与总胆固醇和胆固醇相关，这证实了在这些年轻人的脂质管理中促进更好的代谢控制的重要性。未来的研究应继续探索tHcy和血脂作为1型和2型糖尿病青年CV风险预测因子的有效性。
Background and Research Objective: Limited research is available on the possible differences in the cardiovascular risk factors of total homocysteine (tHcy), dietary energy, and lipids among adolescents with type I diabetes mellitus(DM), type 2 DM, or healthy controls. This study's primary aim was to compare the dietary energy and the intake of macronutrients and micronutrients of folate, and vitamins B-6 and B-12, as well as lipids and tHcy for adolescents with type 1 DM, type 2 DM, and healthy non-DM controls. Subjects and Methods: This secondary analysis of the merging of 2 datasets included the following adolescents: 50 with type 1 DIM, 14 with type 2 DM, and 53 controls. Mean ages for those with type I versus type 2 DM were 15.2 +/- 1.9 versus 16.1 +/- 1.9 years, respectively. Mean age for the controls was 16.5 +/- 1.0 years. Variables included fasting tHcy and lipids, and 24-hour dietary recalls for macronutrients and micronutrients. Hemoglobin A,, was obtained for those with DM. Statistical analyses included one-way analyses of variance, Pearson correlations, and stepwise regression. Results and Conclusions: Adolescents with type 1 DM had the lowest tHcy values (P < .05), which were reflective of the limited extant research with this population. Lipid profiles and dietary energy did not differ significantly among the 3 groups. Hemoglobin A(1c) was related to total cholesterol and triglycericles in those with type 1 DM, confirming the importance of promoting better metabolic control in lipid management for these youth. Future research should continue to explore the validity of tHcy and lipids as predictors of CV risks for youth with type 1 and type 2 DM.