The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms.
The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms.
复制标题
DOI：
10.1007/s005340200037
复制
发表时间：
2002-09
期刊：
影响因子：
--
通讯作者：
S. Yonezawa;A. Nakamura;M. Horinouchi;E. Sato
中科院分区：
文献类型：
--
作者：
S. Yonezawa;A. Nakamura;M. Horinouchi;E. Sato
背景/目的：粘蛋白是高分子量糖蛋白，其具有通过O-糖苷键连接到脱粘蛋白蛋白骨架的寡糖。在这里，我们报告MUC 1粘蛋白的表达，（膜结合粘蛋白），MUC 2粘蛋白（粘液型分泌粘蛋白）和MUC 5AC粘蛋白（胃型分泌粘蛋白）在浸润性导管癌（IDC;n= 46）和导管内乳头状粘液性肿瘤（IPMNs;n= 33）的胰腺，以及这种表达与恶性潜能的关系。为了阐明粘蛋白在IPMN中的精确表达模式，我们将IPMN分为三种组织学亚型;结果：IDC的MUC 1（+）、MUC 2（-）和MUC 5AC（+或-）的表达模式较差。相比之下，IPMN-暗细胞型肿瘤，具有相当有利的结果，显示MUC 1（-），MUC 2（+）和MUC 5AC（+）的模式，IPMN-透明细胞型肿瘤，具有有利的结果，显示MUC 1（-），MUC 2（-）和MUC 5AC（+）的模式。另一方面，IPMN致密细胞型肿瘤显示MUC 1（+）、MUC 2（-）和MUC 5AC（+）的模式。在IPMN-暗细胞型肿瘤的癌性变化显示浸润性生长，浸润性区域获得了MUC 1表达的特点，通常在IDC中看到的，虽然他们的主要非浸润性病变显示没有MUC 1表达。IPMN致密细胞型肿瘤通常表现为高细胞浸润和频繁的MUC 1表达，即使在非侵袭性areas.Conclusions：我们的研究粘蛋白表达模式在IDC和IPMN表明，这种模式可能与胰腺肿瘤的生物学行为和恶性潜能。
Background/Purpose:Mucins are high molecular weight glycoproteins that have oligosaccharides attached to the apomucin protein backbone by O-glycosidic linkages. Here, we report the expression of MUC1 mucin (membrane-bound mucin), MUC2 mucin (intestinal-type secretory mucin), and MUC5AC mucin (gastric-type secretory mucin) in invasive ductal carcinomas (IDCs;n= 46) and intraductal papillary-mucinous neoplasms (IPMNs;n= 33) of the pancreas, and the relationship of this expression with malignant potential.Methods:To clarify the precise expression pattern of mucins in IPMNs, we classified IPMNs into three histologic subtypes; IPMN-dark cell type (n= 19), IPMN-clear cell type (n= 10), and IPMN-compact cell type (n= 4).Results:IDC, with a poor outcome, showed a pattern of MUC1(+), MUC2(−), and MUC5AC(+ or −). In contrast, IPMN-dark cell type tumors, with a fairly favorable outcome, showed a pattern of MUC1(−), MUC2(+), and MUC5AC(+), and IPMN-clear cell type tumors, with a favorable outcome, showed a pattern of MUC1(−), MUC2(−), and MUC5AC(+). On the other hand, IPMN-compact cell type tumors showed a pattern of MUC1(+), MUC2(−), and MUC5AC(+). In IPMN-dark cell type tumors with carcinomatous change showing invasive growth, the invasive areas acquired a characteristic of MUC1 expression that was usually seen in IDC, although their main noninvasive lesions showed no MUC1 expression. The IPMN-compact cell type tumors usually showed high cellular atypia and frequent MUC1 expression, even in the noninvasive areas.Conclusions:Our study of the mucin expression pattern in IDC and IPMN shows that this pattern may be related to the biological behavior of pancreatic tumors and their malignant potential.