Bioinformatics-based identification of SPNS3 (Spinster homolog 3) as a prognostic biomarker of apoptosis resistance in acute myeloid leukemia.
Bioinformatics-based identification of SPNS3 (Spinster homolog 3) as a prognostic biomarker of apoptosis resistance in acute myeloid leukemia.
复制标题
基于生物信息学的 SPNS3（Spinster 同源物 3）鉴定作为急性髓系白血病细胞凋亡抵抗的预后生物标志物
DOI：
10.1080/21655979.2021.1982303
复制
发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Sun A
中科院分区：
文献类型：
--
作者：
Hong Y;Tian X;Wang M;Chen C;Sun A
Spinster同系物3（SPNS 3）属于Spinster（SPNS）家族，参与鞘脂的跨膜转运。然而，SPNS 3在急性髓系白血病（AML）中的功能尚不清楚。本研究从与AML复发相关的基因组中获得SPNS 3，并评估高SPNS 3表达是否诱导AML细胞系的凋亡抗性，这与SPNS 3作为临床预后不良标志物的作用一致。此外，内部串联重复FMS样酪氨酸激酶3（FLT 3-ITD）突变和AC127521.1/ MIR-139/SPNS 3竞争内源性RNA轴被发现调节SPNS 3的表达。此外，我们注意到SPNS 3可能在参与AML微环境维持的鞘氨醇-1-磷酸信号通路中发挥重要作用。这些结果突出了SPNS 3在AML中的抗凋亡作用，并通过生物信息学探索了介导这种作用的潜在机制。缩略语：AML：急性骨髓性白血病; FLT3-ITD：FMS样酪氨酸激酶3的内部串联重复; SPNS 3：spinster同系物3; SPNS 1：spinster同系物1; SPNS 2：spinster同系物2; GO：基因本体; S1 P：鞘氨醇-1-磷酸; ceRNA：竞争性内源性RNA; dAML：诊断时的急性髓性白血病; iAML：诱导化疗后的急性髓性白血病; rAML：复发时的急性髓性白血病; DEG：差异表达基因; BP：生物过程;抄送：细胞成分;主文件：分子功能; MRD：微小残留病; EFS：无事件生存率;操作系统：总生存率;- 你好京都基因和基因组百科全书; SPHK：鞘氨醇激酶。
ABSTRACT Spinster homolog 3 (SPNS3) belongs to the Spinster (SPNS) family which participates in sphingolipid transportation through the cell membrane. However, the functions of SPNS3 in acute myeloid leukemia (AML) are unknown. This study obtained SPNS3 from a gene set that was related to AML relapse and evaluate whether high SPNS3 expression induced apoptosis resistance in an AML cell line, which is consistent with the role of SPNS3 as a marker of poor prognosis in the clinic. Moreover, internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3-ITD) mutation and the AC127521.1/ MIR-139/SPNS3 competing endogenous RNA axis were found to regulate SPNS3 expression. In addition, we noted that SPNS3 may play an important role in the Sphingosine-1-phosphate signal pathway that is involved in the maintenance of the AML microenvironment. These results highlight the anti-apoptosis effect of SPNS3 in AML, and the potential mechanism mediating this effect was explored through bioinformatics. Abbreviations: AML: acute myeloid leukemia; FLT3-ITD: internal tandem duplication of FMS-like tyrosine kinase 3; SPNS3: spinster homolog 3; SPNS1: spinster homolog 1; SPNS2: spinster homolog 2; GO: gene ontology; S1P: sphingosine-1-phosphate; ceRNA: competing endogenous RNA; dAML: acute myeloid leukemia at diagnosis; iAML: acute myeloid leukemia after induction chemotherapy; rAML: acute myeloid leukemia at relapse; DEGs: differentially expressed genes; BP: biological processes; CC: cellular components; MF: molecular functions; MRD: minimal residual disease; EFS: event-free survival; OS: overall survival; KEGG: Kyoto Encyclopedia of Genes and Genomes; SPHK: Sphingosine kinase.
登录
查看更多内容
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1111/cea.13249
发表时间：
2018-12
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Virkud YV;Kelly RS;Croteau-Chonka DC;Celedón JC;Dahlin A;Avila L;Raby BA;Weiss ST;Lasky-Su JA
通讯作者：
Lasky-Su JA
DOI：
10.4049/jimmunol.1200282
发表时间：
2012-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Nijnik A;Clare S;Hale C;Chen J;Raisen C;Mottram L;Lucas M;Estabel J;Ryder E;Adissu H;Sanger Mouse Genetics Project;Adams NC;Ramirez-Solis R;White JK;Steel KP;Dougan G;Hancock RE
通讯作者：
Hancock RE
影响因子：
5.8
作者：
Perland E;Bagchi S;Klaesson A;Fredriksson R
通讯作者：
Fredriksson R
影响因子：
4.5
作者：
Raynaud F;Mina M;Tavernari D;Ciriello G
通讯作者：
Ciriello G