Serum CRP Protein as a Differential Marker in Cancer
Serum CRP Protein as a Differential Marker in Cancer
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DOI：
10.1007/s12013-012-9375-9
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发表时间：
2012-11-01
影响因子：
2.6
通讯作者：
Liu Junlan
中科院分区：
文献类型：
--
作者：
Hu Juan;Wang Qijun;Liu Junlan
本研究的目的是测定癌症患者血清C反应蛋白（CRP）浓度，并与免疫性疾病患者和健康人进行比较，进行判别分析。为此，使用特殊蛋白质自动分析系统（型号：Drcon Diognostica Tarbox）测定276名癌症患者（A组）、110名免疫疾病患者（B组）、161名炎症患者（C组）和125名年龄匹配的健康个体（D组）的血清CRP浓度。我们的数据显示，A组的血清CRP浓度显著高于B和D组，而B组的CRP浓度高于D组。A组与B组、B组与D组间血清CRP浓度差异均有显著性（P < 0.01）。因此，我们得出结论，血清CRP浓度的测量是一种快速，准确的方法来区分癌症和免疫性疾病患者。
The objective of this study was to measure the serum concentrations of C-reactive protein (CRP) in cancer patients and compare with those of immune disease patients and healthy individuals for discriminatory analysis. For this purpose, automatic systems for special protein analysis (Type: Drcon Diognostica Tarbox) was used to measure serum CRP concentrations in 276 cancer patients (Group A), 110 immune disease patients (Group B), 161 phlogistic patients (Group C), and 125 age-matched healthy individuals (Group D). Our data show that serum CRP concentrations in Group A were significantly higher than those in Groups B and D, whereas CRP concentrations in Group B were higher than those in Group D. The differences of serum CRP concentrations between Groups A and B as well as between Groups B and D were significant (P < 0.01). We, therefore, concluded that the measurement of serum CRP concentrations was a fast and accurate method to distinguish between cancer and immune disease patients.