The prevalence of apoE-ε4 in Alzheimer's disease is age dependent
The prevalence of apoE-ε4 in Alzheimer's disease is age dependent
复制标题
DOI：
10.1136/jnnp.65.1.103
复制
发表时间：
1998-07-01
影响因子：
11
通讯作者：
Trabucchi, M
中科院分区：
文献类型：
--
作者：
Frisoni, GB;Manfredi, M;Trabucchi, M
载脂蛋白E的等位基因是阿尔茨海默病的危险因素。然而，可能还涉及其他尚未确定的因素。有研究表明，在60岁之前和80岁之后发病的阿尔茨海默病中，α 4等位基因的相关性可能相对较低。其目的是评估在发病年龄范围内，α 4等位基因与阿尔茨海默病的相关性。156例发病年龄在46 ~ 89岁之间的患者和120例年龄在53 ~ 89岁的认知功能正常者作为对照。发病时的年龄将病例和对照组的年龄分为6组（60岁及以下、60至64岁、65至69岁、70至74岁、75至79岁和80岁及以上）。采用多变量性别调整概率单位回归分析，对各年龄组病例和对照组中的104患病率进行建模。在对照组中，经性别调整的患病率与年龄呈轻微负相关，在最年轻的年龄组中患病率为0.16，在最年长的年龄组中患病率为0.09。阿尔茨海默病患者的性别校正关系呈钟形曲线，最年轻年龄组患病率为0.23，65 ~ 69岁和70 ~ 74岁年龄组分别上升至0.54和0.51，最年长年龄组患病率下降至0.12。结论是，Alzheimer病与α 4等位基因的关系是年龄依赖性的，表明其他危险因素可能与年轻和老年人有关。
The epsilon 4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. However, other yet unidentified factors might be involved. It has been suggested that the epsilon 4 allele might be relatively less relevant in Alzheimer's disease with onset before age 60 and after age 80. The aim was to evaluate the association of the epsilon 4 allele with Alzheimer's disease across a wide range of ages at onset. 156 patients with age at onset between 46 and 89 and 120 cognitively unimpared subjects aged 53 to 89 as controls were studied. Age at onset ill the cases and age in the controls were stratified into six groups (60 and younger, 60 to 64, 65 to 69, 70 to 74, 75 to 79, and 80 and older). Multivariable sex adjusted probit regression analysis was used to model epsilon 4 prevalences in cases and controls across age. The sex adjusted relation of epsilon 4 with age in controls was slightly negative with prevalence of 0.16 in the youngest and 0.09 in the oldest age groups. The sex adjusted relation in cases with Alzheimer's disease had a bell shaped curve with prevalence of 0.23 in the youngest age group, rising to 0.54 and 0.51 in the age groups 65 to 69 and 70 to 74, and decreasing to 0.12 in the oldest age group. it is concluded that the relation of the epsilon 4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages.