Carbon nanoparticle-based fluorescent bioimaging probes.
Carbon nanoparticle-based fluorescent bioimaging probes.
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DOI：
10.1038/srep01473
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发表时间：
2013
影响因子：
4.6
通讯作者：
Jana, Nikhil R.
中科院分区：
文献类型：
--
作者：
Bhunia, Susanta Kumar;Saha, Arindam;Maity, Amit Ranjan;Ray, Sekhar C.;Jana, Nikhil R.
基于荧光纳米颗粒的成像探针具有先进的当前标记技术，并且基于其与常规分子探针相比的上级亮度和光稳定性，有望产生新的医学诊断工具。虽然在基于荧光半导体纳米晶体的生物标记和成像方面取得了重大进展，但重金属的存在以及与重金属相关的毒性问题严重限制了这些纳米晶体的应用潜力。在这里，我们报告了一种基于荧光碳纳米颗粒的，替代的，无毒的成像探针，适用于生物染色和诊断。我们开发了一种化学方法来合成1-10 nm大小的高荧光碳纳米颗粒;这些颗粒表现出尺寸依赖性，可调的可见光发射。 这些碳纳米颗粒已被转化为具有5-15 nm流体动力学直径的各种功能化纳米探针，并已被用作细胞成像探针。
Fluorescent nanoparticle-based imaging probes have advanced current labelling technology and are expected to generate new medical diagnostic tools based on their superior brightness and photostability compared with conventional molecular probes. Although significant progress has been made in fluorescent semiconductor nanocrystal-based biological labelling and imaging, the presence of heavy metals and the toxicity issues associated with heavy metals have severely limited the application potential of these nanocrystals. Here, we report a fluorescent carbon nanoparticle-based, alternative, nontoxic imaging probe that is suitable for biological staining and diagnostics. We have developed a chemical method to synthesise highly fluorescent carbon nanoparticles 1–10 nm in size; these particles exhibit size-dependent, tunable visible emission. These carbon nanoparticles have been transformed into various functionalised nanoprobes with hydrodynamic diameters of 5–15 nm and have been used as cell imaging probes.
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影响因子：
29.4
作者：
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通讯作者：
Pang, Dai-Wen
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作者：
Krysmann, Marta J.;Kelarakis, Antonios;Giannelis, Emmanuel P.
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Giannelis, Emmanuel P.
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影响因子：
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作者：
Bourlinos, Athanasios B.;Stassinopoulos, Andreas;Giannelis, Emmanuel P.
通讯作者：
Giannelis, Emmanuel P.
影响因子：
8.6
作者：
Jana, NR;Chen, YF;Peng, XG
通讯作者：
Peng, XG