Signaling of Gα12 family of g proteins through a tyrosine kinase and a Ras-GAP
Signaling of Gα12 family of g proteins through a tyrosine kinase and a Ras-GAP
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DOI：
10.1016/s1050-1738(00)00054-2
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发表时间：
2000-05-01
影响因子：
9.3
通讯作者：
Huang, XY
中科院分区：
文献类型：
--
作者：
Cvejic, S;Jiang, Y;Huang, XY
G(12) 异三聚体 G 蛋白可转导来自参与心血管功能调节的许多受体的信号。最近发现这些G蛋白通过保守的PH-BM结构域调节布鲁顿酪氨酸激酶和Ras-GAP1(m)的活性。这些发现为 G(12) 启动的信号通路提供了新的见解，该通路调节细胞骨架组织、细胞增殖和心血管功能。 （心血管医学趋势 2000 年；10：160-165）。 (C) 2000，爱思唯尔科学公司。
G(12) heterotrimeric G proteins transduce signals from a number of receptors involved in the regulation of cardiovascular function. Recently, it has been discovered that these G proteins regulate the activity of Bruton's tyrosine kinase and Ras-GAP1(m) through a conserved PH-BM domain. These findings provide new, insights into the signaling pathways initiated by G(12), which regulate cytoskeletal organization, cell proliferation and cardiovascular function. (Trends Cardiovasc Med 2000;10:160-165). (C) 2000, Elsevier Science Inc.