Light in and sound out: emerging translational strategies for photoacoustic imaging.
Light in and sound out: emerging translational strategies for photoacoustic imaging.
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DOI：
10.1158/0008-5472.can-13-2387
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发表时间：
2014-02-15
期刊：
影响因子：
11.2
通讯作者：
Gambhir SS
中科院分区：
文献类型：
--
作者：
Zackrisson S;van de Ven SMWY;Gambhir SS
光声成像具有高分辨率和深入组织内部的实时分子成像的潜力，使用非电离辐射，而不一定依赖于外源性显像剂，使该技术在一系列临床应用中非常有前景。光声成像系统的便携性和与现有成像技术的兼容性更有利于临床转译。光声学可以发挥重要作用的临床应用范围包括：乳房、前哨淋巴结、皮肤、甲状腺、眼睛、前列腺（经直肠）和卵巢（经阴道）的无创成像；胃肠道、膀胱和循环肿瘤细胞的微创内镜成像（体内流式细胞术）；术中影像学用于评估肿瘤边缘和（淋巴结）转移。在这篇综述中，我们描述了光声成像的基础知识及其在生物医学研究中的最新进展，然后讨论了该技术的临床翻译策略。
Photoacoustic imaging has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using non-ionizing radiation and not necessarily depending on exogenous imaging agents, making this technique very promising for a range of clinical applications. The fact that photoacoustic imaging systems can be made portable and compatible with existing imaging technologies favors clinical translation even more. The breadth of clinical applications in which photoacoustics could play a valuable role include: noninvasive imaging of the breast, sentinel lymph nodes, skin, thyroid, eye, prostate (transrectal), and ovaries (transvaginal); minimally invasive endoscopic imaging of gastrointestinal tract, bladder, and circulating tumor cells (in vivo flow cytometry); and intraoperative imaging for assessment of tumor margins and (lymph node) metastases. In this review we describe the basics of photoacoustic imaging and its recent advances in biomedical research, followed by a discussion of strategies for clinical translation of the technique.