Left ventricular ejection fraction and left ventricular end-diastolic volume in patients with diastolic dysfunction.
Left ventricular ejection fraction and left ventricular end-diastolic volume in patients with diastolic dysfunction.
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舒张功能障碍患者的左心室射血分数和左心室舒张末期容积。
DOI：
10.1111/chf.12013
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wackers,FransJ
中科院分区：
文献类型：
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作者：
Jovin,IonS;Ebisu,Keita;Liu,Yi-Hwa;Finta,LaurieA;Oprea,AdrianaD;Brandt,CynthiaA;Dziura,James;Wackers,FransJ
舒张功能障碍可以通过平衡法放射性核素心血管造影（ERNA）在左心室射血分数（LVEF）正常的情况下通过低峰值充盈率（PFR）诊断。作者评价了舒张功能障碍、LVEF和舒张末期容积（EDV）之间的关系。共研究了408例ERNA测定LVEF ≥50%的主要无症状患者。将低PFR患者的LVEF与正常PFR患者的LVEF进行比较。还进行了相关性分析，以评估PFR和EDV之间的关联。低PFR患者的LVEF低于正常PFR患者的LVEF（59±7 vs 63%±7%;P<0.01）。EDV和PFR之间没有相关性（r=-0.04;P= 0.32）。当使用EDV指数时，结果没有改变。在重复扫描的患者中，EDV的变化与PFR的变化之间没有相关性（r=0.16;P= 0.2）。在收缩功能正常的无症状ERNA患者中，低PFR可能与较低的LVEF相关，但与EDV变化无关。这表明舒张功能障碍与轻度收缩功能障碍有关。
Diastolic dysfunction can be diagnosed on equilibrium radionuclide angiocardiography (ERNA) by a low peak filling rate (PFR) in the setting of a normal left ventricular ejection fraction (LVEF). The authors evaluated the relationship between diastolic dysfunction, LVEF, and end‐diastolic volume (EDV). A total of 408 predominantly asymptomatic patients with an LVEF ≥50% by ERNA were studied. LVEF of patients with a low PFR was compared with the LVEF of patients with a normal PFR. Correlation analyses to evaluate the association between PFR and EDV were also performed. The LVEF of patients with a low PFR was lower than the LVEF of patients with normal PFR (59±7 vs 63%±7%;P<.01). There was no correlation between EDV and PFR (r=−0.04;P=.32). The results did not change when the EDV indices were used. In patients who had repeat scans, there was no correlation between the change in EDV and the change in PFR (r=0.16;P=.2). In asymptomatic patients undergoing ERNA who have normal systolic function, a low PFR can be associated with a lower LVEF, but it is not associated with changes in EDV. This suggests that diastolic dysfunction is associated with mild systolic dysfunction.