Characteristics of basal insulin requirements by age and gender in Type-1 diabetes patients using insulin pump therapy
Characteristics of basal insulin requirements by age and gender in Type-1 diabetes patients using insulin pump therapy
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DOI：
10.1016/j.diabres.2004.11.005
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Boyer, BA
中科院分区：
文献类型：
--
作者：
Scheiner, G;Boyer, BA
Establishment of appropriate basal insulin levels is an essential component of intensive insulin therapy. While the existence of a "dawn phenomenon" is widely recognized, the present study sought to establish whether diurnal basal insulin patterns exist in Type-1 diabetes, and whether these patterns vary by age and gender. Participant data was drawn from 322 Type-1 insulin pump users treated at a private diabetes education practice in suburban Philadelphia. All participants completed a battery of fasting tests designed to match basal insulin levels to endogenous glucose production and insulin sensitivity. Analysis of resultant basal patterns revealed significant differences between juvenile (age 20) basal insulin patterns. The younger group exhibited a more pronounced and sustained night-time peak; the older group exhibiting a briefer and less pronounced early-morning peak. Lower overall basal insulin requirements were found in the youngest (age 60) groups. No noteworthy gender differences were found. Results can serve as a guide for clinicians when initiating and fine-tuning patients who utilize basal/bolus insulin therapy. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
