The role of the microenvironment in the biophysics of cancer.
The role of the microenvironment in the biophysics of cancer.
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DOI：
10.1016/j.semcdb.2017.07.022
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发表时间：
2018
影响因子：
7.3
通讯作者：
Carmela Rianna;Prem Kumar;M. Radmacher
中科院分区：
文献类型：
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作者：
Carmela Rianna;Prem Kumar;M. Radmacher
在过去的几十年中，细胞力学已被公认为是一种定量的措施，以区分许多生理和病理状态的单细胞。在癌症的生物物理学领域，大量的研究集中在正常和癌症力学之间的比较上，并且慢慢地，癌细胞比其正常对应物更软的假设已经被接受，即使原位肿瘤组织通常比周围的正常组织更硬。这证实了细胞外基质（ECM）在调节肿瘤细胞特性和行为中具有关键作用的观点。ECM中的重排可以导致癌细胞力学的变化，并且在特定条件下，关于癌细胞软化的一般假设可能会受到质疑。在这里，我们强调了ECM在癌细胞力学中的贡献，并认为癌细胞比正常细胞更柔软的说法应该与细胞环境的特性和癌细胞进展的特定阶段密切相关。特别是，我们将讨论在癌症诊断和鉴别中使用细胞力学时，微环境的化学，地形和-最后但并非最不重要的-机械特性非常重要。
During the last decades, cell mechanics has been recognized as a quantitative measure to discriminate between many physiological and pathological states of single cells. In the field of biophysics of cancer, a large body of research has been focused on the comparison between normal and cancer mechanics and slowly the hypothesis that cancer cells are softer than their normal counterparts has been accepted, even though in situ tumor tissue is usually stiffer than the surrounding normal tissue. This corroborates the idea that the extra-cellular matrix (ECM) has a critical role in regulating tumor cell properties and behavior. Rearrangements in ECM can lead to changes in cancer cell mechanics and in specific conditions the general assumption about cancer cell softening could be confuted. Here, we highlight the contribution of ECM in cancer cell mechanics and argue that the statement thatcancer cells are softer than normal cellsshould be firmly related to the properties of cell environment and the specific stage of cancer cell progression. In particular, we will discuss that when employing cell mechanics in cancer diagnosis and discrimination, the chemical, the topographical and − last but not least − the mechanical properties of the microenvironment are very important.