Evaluation of a sustained-release formulation of buprenorphine for analgesia in rats.
Evaluation of a sustained-release formulation of buprenorphine for analgesia in rats.
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丁丙诺啡缓释制剂对大鼠镇痛作用的评价。
DOI：
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发表时间：
2011
影响因子：
1.7
通讯作者：
A. Crichlow
中科院分区：
文献类型：
--
作者：
P. Foley;Haixiang Liang;A. Crichlow
预防和最大限度地减少实验动物的疼痛是生物医学研究的基本原则，并且出于伦理、法律的和科学原因而得到保证。术后镇痛是疼痛管理的一个重要方面。在大鼠中测试丁丙诺啡的缓释制剂的镇痛功效和72小时时间段内的血浆浓度。向大鼠皮下注射1.2 mg/kg缓释制剂（Bup-SR）、0.2 mL/kg盐酸丁丙诺啡（Bup-HCl）或等体积的缓释载体，并在热伤害感受模型或手术后疼痛模型中进行测试。在这两种模型中，Bup-SR显示出提供镇痛2至3天的证据。与第1天和第2天的基线值相比，接受缓释制剂的大鼠的热潜伏期反应分别增加了28.4%和15.6%。单皮质胫骨缺损和Bup-SR治疗的大鼠表现出类似的意愿，承担后肢的重量阴性对照动物（无手术），证明了通过计数垂直提升; Bup-HCl治疗的大鼠有显着较少的垂直提升比对照大鼠手术后5天。丁丙诺啡的血浆浓度保持超过1 ng/mL的单剂量的Bup-SR后72小时。两者合计，结果表明，这种配方的丁丙诺啡可能是一个可行的选择，用于治疗手术后疼痛的实验室大鼠。
Preventing and minimizing pain in laboratory animals is a basic tenet of biomedical research and is warranted for ethical, legal, and scientific reasons. Postoperative analgesia is an important facet of pain management. A sustained-release formulation of buprenorphine was tested in rats for analgesic efficacy and plasma concentration over a 72-h time period. Rats were injected subcutaneously with either 1.2 mg/kg sustained-release formulation (Bup-SR), 0.2 mL/kg buprenorphine HCl (Bup-HCl), or an equivalent volume of sustained-release vehicle and tested in a thermal nociception model or a surgical postoperative pain model. In both models, Bup-SR showed evidence of providing analgesia for 2 to 3 d. Thermal latency response in rats that received the sustained-release formulation increased 28.4% and 15.6% compared with baseline values on days 1 and 2, respectively. Rats with a unicortical tibial defect and treated with Bup-SR showed similar willingness to bear weight on the hindlimbs as did negative-control animals (no surgery), demonstrated by counting vertical raises; rats treated with Bup-HCl had significantly fewer vertical raises than did control rats for 5 d after surgery. Plasma concentrations of buprenorphine remained over 1 ng/mL for 72 h after a single dose of Bup-SR. Taken together, the results indicate that this formulation of buprenorphine may be a viable option for treating postsurgical pain in laboratory rats.
雄性大鼠在接受各种止痛药治疗后从腹部大手术中恢复。
DOI：
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发表时间：
2003
期刊：
Contemporary topics in laboratory animal science
影响因子：
--
作者：
Sharp,Jody;Zammit,Timothy;Azar,Toni;Lawson,David
通讯作者：
Lawson,David
两种阿片类镇痛药缓解大鼠肠切除引起的内脏疼痛的比较。
DOI：
--
发表时间：
2001
期刊：
Contemporary topics in laboratory animal science
影响因子：
--
作者：
Gillingham,MB;Clark,MD;Dahly,EM;Krugner-Higby,LA;Ney,DM
通讯作者：
Ney,DM
脂质体封装的盐酸羟吗啡酮可长期缓解大鼠术后内脏疼痛。
DOI：
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发表时间：
2003
期刊：
Comparative medicine.
影响因子：
--
作者：
Krugner-Higby,Lisa;Smith,Lesley;Clark,Melanee;Heath,TimothyD;Dahly,Elizabeth;Schiffman,Beth;Hubbard-VanStelle,Scott;Ney,Denise;Wendland,Allyson
通讯作者：
Wendland,Allyson