Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult
Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult
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DOI：
10.1179/016164103771953862
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Pocock, D
中科院分区：
文献类型：
--
作者：
Kleim, JA;Bruneau, R;Pocock, D
卒中后运动功能的恢复被认为至少部分是由残神经组织的功能代偿支持的。本研究采用啮齿类动物局灶性缺血和皮质内微刺激（ICMS）模型，研究皮质刺激联合运动康复对行为和生理的影响。成年大鼠在被训练的前爪对侧的前肢运动皮层中获得运动表征图之前，被训练成一个单一的颗粒到达任务。然后所有动物在运动图内接受局灶性缺血性梗死。在运动皮层上植入皮质表面电极。在10天的康复训练中，对相同的到达任务施加低水平的电刺激，并使用ICMS获得第二个运动图。结果表明，单极和双极皮质刺激均能显著增强运动恢复，并增加了可引起微刺激运动的皮质面积。结果表明，脑皮层刺激结合康复治疗对脑卒中患者的行为和神经生理都有益处。
Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimulation in combination with motor rehabilitation. Adult rats were trained to criterion on a single pellet reaching task before ICMS was used to derive maps of movement representations within forelimb motor cortex contralateral to the trained paw. All animals then received a focal ischemic infarct within the motor map. A cortical surface electrode was implanted over the motor cortex. Low levels of electrical stimulation were applied during rehabilitative training on the same reaching task for 10 days and ICMS used to derive a second motor map. Results showed that both monopolar and bipolar cortical stimulation significantly enhanced motor recovery and increased the area of cortex from which microstimulation movements could he evoked. The results demonstrate the behavioral and neurophysiological benefits of cortical stimulation in combination with rehabilitation for recovery from stroke.