Illustrating idiographic methods for translation research: moderation effects, natural clinical experiments, and complex treatment-by-subgroup interactions.
Illustrating idiographic methods for translation research: moderation effects, natural clinical experiments, and complex treatment-by-subgroup interactions.
复制标题
阐释翻译研究的具体方法：调节效应、自然临床实验和复杂的亚组治疗相互作用。
DOI：
10.1007/s13142-015-0357-5
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发表时间：
2016
影响因子：
3.6
通讯作者：
Kane-Gill,Sandra
中科院分区：
文献类型：
--
作者：
Ridenour,TyA;Wittenborn,AndreaK;Raiff,BethanyR;Benedict,Neal;Kane-Gill,Sandra
翻译研究的一个关键时刻涉及对干预工具、提供者培训计划、政策和其他机制的初步研究，这些机制用于将在一个翻译阶段获得的知识利用到另一个阶段。对此类研究可能有用的是进行受试者内临床试验的严格技术，这些技术在过去十年中逐步发展。然而，这些方法在很大程度上没有在预防或翻译背景下使用。这篇文章的目的是为了证明干预机制初步测试的具体临床试验的灵活性、广泛适用性和严谨性。具体证明了状态空间建模的新用途，用于测试短期结果的干预机制，识别人内治疗机制的异质性和适度性，在基于临床的实验研究过程中改进抽样设计的水平线图，以及当治疗沿着（例如，传统的12个月结果）。
A critical juncture in translation research involves the preliminary studies of intervention tools, provider training programs, policies, and other mechanisms used to leverage knowledge garnered at one translation stage into another stage. Potentially useful for such studies are rigorous techniques for conducting within-subject clinical trials, which have advanced incrementally over the last decade. However, these methods have largely not been utilized within prevention or translation contexts. The purpose of this manuscript is to demonstrate the flexibility, wide applicability, and rigor of idiographic clinical trials for preliminary testing of intervention mechanisms. Specifically demonstrated are novel uses of state-space modeling for testing intervention mechanisms of short-term outcomes, identifying heterogeneity in and moderation of within-person treatment mechanisms, a horizontal line plot to refine sampling design during the course of a clinic-based experimental study, and the need to test a treatment's efficacy as treatment is administered along with (e.g., traditional 12-month outcomes).