Metabolism of the carcinogen chromate by rat liver microsomes.
Metabolism of the carcinogen chromate by rat liver microsomes.
复制标题
大鼠肝微粒体对致癌物质铬酸盐的代谢。
DOI：
10.1016/0006-291x(78)90931-2
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发表时间：
1978
影响因子：
3.1
通讯作者：
K. Jennette
中科院分区：
文献类型：
--
作者：
J. Gruber;K. Jennette
本文研究了铬酸盐在大鼠肝微粒体中的代谢。在酶辅因子NADPH存在下，铬酸盐与微粒体孵育导致铬酸盐还原。在不存在NADPH的情况下，未发生还原。在不存在微粒体的情况下，使用NADPH仅观察到少量铬酸盐还原。时程研究、微粒体和NADPH浓度依赖性研究导致铬酸盐完全还原的条件。本文还讨论了铬酸盐的致癌性和致突变性与其代谢的可能关系。
The metabolism of chromate by rat liver microsomes has been studied. Incubation of chromate with microsomes in the presence of the enzyme cofactor NADPH, resulted in reduction of chromate. In the absence of NADPH no reduction occurred. Only a small amount of chromate reduction was seen with NADPH in the absence of microsomes. Time course studies, microsome and NADPH concentration dependence studies resulted in conditions giving complete reduction of chromate. The possible relationship of metabolism of chromate to its carcinogenicity and mutagenicity is discussed.