Size matters: formation and function of giant synapses.
Size matters: formation and function of giant synapses.
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大小很重要：巨型突触的形成和功能。
DOI：
10.1113/jphysiol.2013.258954
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Borst,JGerardG
中科院分区：
文献类型：
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作者：
Forsythe,IanD;Wu,Chunlai;Borst,JGerardG
本次研讨会于2012年10月12日星期五在新奥尔良举行，由路易斯安那州立大学神经科学卓越中心主办，由生理学杂志和生理学会赞助。会议汇集了几个神经科学团体，他们对哺乳动物和无脊椎动物神经系统中大型突触的发育和功能有不同的看法，包括CNS突触和神经肌肉接头（NMJ）的外周突触，并考虑突触前和突触后界面。对于突触，大小是其影响目标的潜在力量的明确预测因素（Petrof &谢尔曼，2013）。在大多数情况下，单个神经元整合来自数千个突触的信息，但在某些情况下（如NMJ和Held萼），很大一部分突触输入来自一个占主导地位的轴突末端。突触生理学家青睐巨型突触，因为它们具有可接近性，我们关于突触传递的许多知识都是从这些巨型突触中学到的，包括鱿鱼巨型突触和青蛙NMJ。NMJ独特的可访问性使发育神经生物学家能够阐明突触组装所需的关键因素。近年来，遗传标记和成像方法的技术突破相结合，说明了大也是美丽的，正如研究所证明的那样，
This symposium took place as a satellite of the Society for Neuroscience Meeting in New Orleans on Friday 12 October 2012, hosted by the Neuroscience Center of Excellence at Louisiana State University and sponsored by The Journal of Physiology and The Physiological Society. The meeting drew together several neuroscience communities with differing perspectives on development and function at large synapses in both mammalian and invertebrate nervous systems, including both CNS synapses and peripheral synapses of the neuromuscular junction (NMJ) and considering both pre-and postsynaptic interfaces.For a synapse, size is a clear predictor of its potential power in influencing the target (Petrof & Sherman, 2013). In most cases, single neurons integrate information from many thousands of synapses, but in some cases (such as the NMJ and the calyx of Held) a very high proportion of the synaptic input arises from one dominant axon terminal. Synaptic physiologists have favoured giant synapses for their accessibility, and much of our knowledge about synaptic transmission has been learned from these giant synapses, including the squid giant synapse and the frog NMJ. The unique accessibility of the NMJ has allowed developmental neurobiologists to elucidate the key factors required for synapse assembly. In recent times, a combination of technical breakthroughs in genetic labelling and imaging methods has illustrated that big is also beautiful, as evidenced by studies in which