Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest.
Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest.
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DOI：
10.12703/r/12-5
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发表时间：
2023
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细胞增殖控制在发育期间和维持成体组织是必不可少的。这种控制的丧失不仅在细胞不适当地增殖时促进肿瘤发生，而且在细胞不能在需要的时候和需要的地方增殖时促进发育异常或退化。为了确保在正确的地点和时间产生细胞，促增殖和抗增殖信号的复杂平衡影响细胞经历细胞周期退出到静止期或G0期的可能性。这篇简短的综述描述了我们对哺乳动物细胞如何以及何时启动和维持静止的理解的最新进展。我们强调，越来越多的赞赏静止作为一个集合的上下文相关的不同状态。
Cell proliferation control is essential during development and for maintaining adult tissues. Loss of that control promotes not only oncogenesis when cells proliferate inappropriately but also developmental abnormalities or degeneration when cells fail to proliferate when and where needed. To ensure that cells are produced at the right place and time, an intricate balance of pro-proliferative and anti-proliferative signals impacts the probability that cells undergo cell cycle exit to quiescence, or G0 phase. This brief review describes recent advances in our understanding of how and when quiescence is initiated and maintained in mammalian cells. We highlight the growing appreciation for quiescence as a collection of context-dependent distinct states.