Glucocorticoid-induced lymphocytolysis: state of the genetic analysis.
Glucocorticoid-induced lymphocytolysis: state of the genetic analysis.
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糖皮质激素诱导的淋巴细胞溶解：遗传分析的状态。
DOI：
10.1002/jss.400130311
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Bourgeois,S
中科院分区：
文献类型：
--
作者：
Bourgeois,S
糖皮质激素诱导的淋巴细胞系溶解为类固醇激素作用提供了一种遗传方法，因为可以很容易地选择对这种溶解作用具有抗性的无反应变体。本文综述了两种小鼠细胞系S49 T淋巴瘤和W7胸腺瘤的淋巴细胞溶解分析现状。迄今为止分离出的所有糖皮质激素耐药变体都是由糖皮质激素受体的各种缺陷引起的。在裂解机制的另一个步骤中阻断的变体的情况下进行了讨论。观察到的糖皮质激素受体基因座的半合子在S49线和细胞杂交的不稳定性说明了一些潜在的问题，在体细胞遗传学中遇到的。
The glucocorticoid‐induced lysis of lymphoid cell lines offers a genetic approach to steroid hormone action because unresponsive variants can easily be selected as resistant to this lytic effect. The present state of analysis of lymphocytolysis in two murine cell lines, the S49 T‐lymphoma and the W7 thymoma, is reviewed. All glucocorticoid‐resistant variants isolated so far result from various defects in the glucocorticoid receptor. The absence of variants blocked at another step of the lytic mechanism is discussed. The observed hemizygosity of the glucocorticoid receptor locus in the S49 line and the instability of cell hybrids illustrate some of the potential problems encountered in somatic cell genetics.