BALB/c mice: Low sociability and other phenotypes that may be relevant to autism
BALB/c mice: Low sociability and other phenotypes that may be relevant to autism
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DOI：
10.1016/j.bbr.2006.06.025
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发表时间：
2007-01-10
影响因子：
2.7
通讯作者：
Brodkin, Edward S.
中科院分区：
文献类型：
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作者：
Brodkin, Edward S.
社交能力低下是自闭症最突出和最严重的症状之一。社交能力的生物学原理尚不清楚，并且没有可用的治疗方法可以充分改善大多数自闭症患者的社交功能。社交能力下降的动物模型的开发有助于阐明社会行为的生物学，并可能最终揭示自闭症的生物学。本文将回顾 BALB/c 近交系小鼠在不同环境和不同发育阶段表现出相对较低水平的社交互动的证据，包括男性与男性之间的互动、女性与女性之间的互动、男性与女性之间的性互动和养育行为。综上所述，这些证据表明 BALB/c 小鼠的社交能力普遍较低，这可能与自闭症有关。 BALB/c 小鼠还表现出可能与自闭症相关的其他表型，包括相对较高水平的焦虑和攻击行为、大脑体积较大、胼胝体发育不良以及大脑血清素水平较低。需要进一步的研究来确定这些 BALB/c 表型之间的关系，并确定它们与自闭症可能的相关性。总之，BALB/c 近交系可能是鉴定与自闭症相关表型相关的基因和神经生物学途径的有用动物模型。 (c) 2006 Elsevier B.V. 保留所有权利。
Low sociability is one of the most prominent and disabling symptoms of autism. The biology of sociability is not well understood, and there is no available treatment that adequately improves social functioning in most autistic patients. The development of animal models of reduced sociability can aid in the elucidation of the biology of social behaviors, and may ultimately shed light on the biology of autism. This paper will review evidence that mice of the BALB/c inbred strain show relatively low levels of social interaction in various settings and across various stages of development, including male-male interactions, female-female interactions, male-female sexual interactions, and parenting behaviors. Taken together, this evidence suggests a generally low level of sociability in BALB/c mice that may be relevant to autism. BALB/c mice also show other phenotypes with possible relevance to autism, including relatively high levels of anxiety and aggressive behaviors, large brain size, underdevelopment of the corpus callosum, and low levels of brain serotonin. Further research is needed to determine the relationship among these BALB/c phenotypes, and to determine their possible relevance to autism. In conclusion, the BALB/c inbred strain may be a useful animal model for identifying genes and neurobiological pathways involved in autism-related phenotypes. (c) 2006 Elsevier B.V. All rights reserved.