Involvement of type I immune responses in swine-origin H1N1 influenza virus infection
Involvement of type I immune responses in swine-origin H1N1 influenza virus infection
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DOI：
10.1016/j.humimm.2011.04.006
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发表时间：
2011-08-01
期刊：
影响因子：
2.7
通讯作者：
Batocchi, Anna Paola
中科院分区：
文献类型：
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作者：
Frisullo, Giovanni;Iorio, Raffaele;Batocchi, Anna Paola
猪源性H1N1流感病毒（S-OIV）于2009年出现，儿童发病率较高。虽然发烧是最常见的症状，但也有一些复杂的病例。我们评估了5例S-OIV感染儿童（1例急性坏死性脑炎，2例肺炎，2例无并发症）、5例季节性流感儿童和5例健康儿童外周血中效应T细胞、B细胞和调节性T细胞的百分比。我们发现，在患有季节性流感和H1N1流感的儿童中，T-bet(+) CD4(+)CD8(+) T细胞、单核细胞和B细胞、颗粒酶B+和穿孔素（+）CD4（+）和CD8(+) T细胞的百分比高于对照组，而两组的CD4(+)CD25(+)Foxp3（+）调节性T细胞的百分比相似。在有并发症的感染儿童中，我们观察到高百分比的穿孔素（+）和干扰素γ (+) CD4（+）和CD8(+) T细胞与低百分比的T调节细胞相关。我们的数据表明，在复杂的S-OIV感染中，抗病原体I型免疫反应失调。(C) 2011年美国组织相容性和免疫遗传学学会。Elsevier Inc.出版。版权所有。
Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet(+) CD4(+)CD8(+) T cells, monocytes, and B cells, granzyme B+ and perforin(+) CD4(+), and CD8(+) T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4(+)CD25(+)Foxp3(+) regulatory T cells. In infected children with complications we observed high percentages of perforin(+) and interferon-gamma(+) CD4(+) and CD8(+) T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.