Toenail selenium and cardiovascular disease in men with diabetes
Toenail selenium and cardiovascular disease in men with diabetes
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DOI：
10.1080/07315724.2005.10719472
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发表时间：
2005-08-01
影响因子：
3.5
通讯作者：
Hu, F
中科院分区：
文献类型：
--
作者：
Rajpathak, S;Rimm, E;Hu, F
目的：硒作为谷胱甘肽过氧化物酶的一种成分可能有益于胰岛素抵抗，因此可能会改变糖尿病和心血管疾病（CVD）的风险。本研究的目的是评估脚趾甲硒和心血管疾病之间的关联男性diabetes.Methods：我们进行了横断面和巢式病例对照分析内的卫生专业人员随访研究，一个队列的男性年龄在40至75岁，在1986年。横断面分析比较了健康对照组（n = 361）与仅患有糖尿病的男性（n = 688）以及患有糖尿病和CVD的男性（n = 198）。巢式病例对照研究包括202名在随访期间发生CVD的糖尿病男性和361名匹配的对照。结果：在控制了潜在的混杂因素后，糖尿病患病的优势比（OR）为0.43（95%CI：0.28，0.64; p趋势
Objective: Selenium as a component of glutathione peroxidase may be beneficial in insulin resistance, hence potentially may modify the risk of diabetes and cardiovascular disease (CVD). The aim of this study is to evaluate the association between toenail selenium and CVD among men with diabetes.Methods: We performed cross-sectional and nested case-control analyses within the Health Professionals Follow-up Study, a cohort of men aged 40 to 75 years in 1986. The cross-sectional analysis compared healthy controls (n = 361) to men with diabetes only (n = 688), and men with prevalent diabetes and CVD (n = 198). The nested case-control study included 202 diabetic men who developed incident CVD during follow-up and 361 matched controls.Results: After controlling for potential confounders, the odds ratio (OR) for prevalent diabetes was 0.43 (95% Cl: 0.28, 0.64; p-trend