Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.
Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.
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DOI：
10.1016/j.semcancer.2015.09.015
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发表时间：
2016-02
影响因子：
14.5
通讯作者：
Abbas T
中科院分区：
文献类型：
--
作者：
Heo J;Eki R;Abbas T
F-box蛋白是SCF（SKP 1-Cullin 1-F-box protein）E3泛素连接酶的底物受体，在许多生理过程和活动中发挥重要作用。通过它们组装不同的E3泛素连接酶和靶向泛素化和降解的细胞活性的关键调节因子的能力，这种多功能的蛋白质组能够调节其失调表达或活性导致疾病的细胞蛋白质的丰度。在这篇综述中，我们描述了选择F-盒蛋白在调节细胞活动中的重要作用，其扰动有助于一些人类恶性肿瘤的发生和发展。
F-box proteins are substrate receptors of the SCF (SKP1-Cullin 1-F-box protein) E3 ubiquitin ligase that play important roles in a number of physiological processes and activities. Through their ability to assemble distinct E3 ubiquitin ligases and target key regulators of cellular activities for ubiquitylation and degradation, this versatile group of proteins is able to regulate the abundance of cellular proteins whose deregulated expression or activity contributes to disease. In this review, we describe the important roles of select F-box proteins in regulating cellular activities, the perturbation of which contributes to the initiation and progression of a number of human malignancies.