Diversion of duodenal contents: its effect on the production of experimental gastric cancer.
Diversion of duodenal contents: its effect on the production of experimental gastric cancer.
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十二指肠内容物的转移：其对实验性胃癌产生的影响。
DOI：
10.1001/archsurg.1980.01380080053010
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发表时间：
1980
影响因子：
--
通讯作者：
G. Barrows
中科院分区：
文献类型：
--
作者：
T. Wieman;M. Max;C. Voyles;G. Barrows
胃肠吻合术和迷走神经切断术后十二指肠内容物的改道并不能保护240只实验大鼠免受胃癌风险的增加。随机分为3组，每组80只：第1组胃窦黏膜下注射0.9 mg 3-甲基胆蒽；第2、3组双侧迷走神经干切断胃肠吻合术，吻合口附近胃粘膜下层注入致癌物；第3组十二指肠全转流术。8个月后，对存活的大鼠进行盲法组织病理学检查，发现60只大鼠中有6只(10%)、71只大鼠中有23只(33%)、27只大鼠中有7只(22%)发生了癌症。与第1组相比，第2组和第3组的胃癌发病率有所增加，但在这方面彼此没有区别。
Diversion of duodenal contents after gastroenterostomy and vagotomy did not protect 240 laboratory rats from increased risk of gastric carcinoma. They were divided into three groups of 80: group 1 received 0.9 mg of 3-methylcholanthrene injected submucosally into the gastric antrum; groups 2 and 3 had bilateral truncal vagotomy and gastroenterostomy, with carcinogen injected into the gastric submucosa near the anastomosis; group 3 also had total duodenoenteric diversion. Blind histopathologic examination of surviving rats during necropsy eight months later disclosed that cancer had developed in six of 60 (10%) group 1 rats, in 23 of 71 (33%) group 2 rats, and in seven of 27 (22%) group 3 rats. Compared with group 1, groups 2 and 3 had an increased incidence of gastric cancer but did not differ from one another in this regard.