Atrial fibrillation is associated with severe acute ischemic stroke
Atrial fibrillation is associated with severe acute ischemic stroke
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DOI：
10.1159/000068743
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发表时间：
2003-03-01
影响因子：
5.7
通讯作者：
Levine, RL
中科院分区：
文献类型：
--
作者：
Dulli, DA;Stanko, H;Levine, RL
心房颤动（AF）是老年人致残性缺血性卒中的常见危险因素，但其严重程度是否普遍比其他病因所致的缺血性卒中更严重尚不清楚。我们回顾了1990年至2001年间收治的急性缺血性卒中患者的临床表现。还使用完善的标准对这些卒中的病因进行了分类。在1,061例急性缺血性卒中患者中，216例（20.3%）有AF。AF患者卧床不起的频率为41.2%，而无AF患者为23.7%（p < 0.0005）。临床卒中严重程度的其他测量结果显示，这些组之间存在类似的差异。多因素Logistic回归分析显示，房颤导致缺血性卒中后卧床不起的优势比为2.23（95% CI = 1.87-2.59，p < 0.0005）。与AF相关的缺血性卒中通常比其他病因引起的缺血性卒中更严重，这种严重程度的增加与高龄和其他卒中风险因素无关。版权所有（C）2003 S. Karger AG，巴塞尔。
Atrial fibrillation (AF) is a common risk factor for disabling ischemic stroke in the elderly, but it is not clear that its severity is generally worse than that of ischemic stroke due to other etiologies. We reviewed the clinical presentations of patients with acute ischemic stroke admitted between 1990 and 2001. The etiologies of these strokes were also classified using well-established criteria. Of 1,061 patients with acute ischemic stroke, 216 (20.3%) had AF. The frequency of bedridden state was 41.2% in patients with AF, compared to 23.7% in patients without AF (p < 0.0005). Other measures of clinical stroke severity showed similar disparities between these groups. The odds ratio for bedridden state following ischemic stroke due to AF was 2.23 (95% Cl = 1.87-2.59, p < 0.0005) by multivariate logistic regression. Ischemic stroke associated with AF is typically more severe than ischemic stroke due to other etiologies, and this increased severity is independent of advanced age and other stroke risk factors. Copyright (C) 2003 S. Karger AG, Basel.