Natural Gum Reduced/Stabilized Gold Nanoparticles for Drug Delivery Formulations
Natural Gum Reduced/Stabilized Gold Nanoparticles for Drug Delivery Formulations
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DOI：
10.1002/chem.200801093
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发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Prasad, B. L. V.
中科院分区：
文献类型：
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作者：
Dhar, Sheetal;Reddy, E. Maheswara;Prasad, B. L. V.
“结冷胶”作为增稠剂和胶凝剂广泛用于食品和医药工业，已被用作合成金纳米颗粒的还原剂和稳定剂。相对于传统的柠檬酸盐和硼氢化物还原的纳米颗粒，这些纳米颗粒对电解质添加和pH变化显示出更大的稳定性。随后这些被用来装载蒽环类抗生素盐酸阿霉素。载药纳米粒对人脑胶质瘤细胞系LN-18和LN-229的细胞毒作用增强。
"Gellan Gum", widely used in food and confectionary industry as a thickening and gelling agent, has been employed as a reducing and stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition and pH changes relative to the traditional citrate and borohydride reduced nanoparticles. Subsequently these have been used to load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on these nanoparticles showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229.