Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma
Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma
复制标题
DOI：
10.1007/s00432-007-0316-8
复制
发表时间：
2008-05-01
影响因子：
3.6
通讯作者：
Xia, Jian-chuan
中科院分区：
文献类型：
--
作者：
Wang, Hui;Pan, Ke;Xia, Jian-chuan
目的研究多梳型基因Bmi-1在小鼠前细胞淋巴瘤中的表达，并发现Bmi-1在多种人类肿瘤中的过表达，随着肿瘤的进展和患者预后的恶化，Bmi-1在肝癌中的表达与预后的关系。结果29.9%的肝癌组织中Bmi-1高表达（Bmi-1 2+或3+）。Bmi-1不仅在高、中分化的肿瘤细胞中呈阳性表达，而且在癌旁组织和肝硬化组织中也呈阳性表达。Bmi-1表达水平与任何临床病理参数均无相关性。然而，生存分析显示高Bmi-1组的总生存时间显著短于低Bmi-1组（P = 0.047）。24个月后的多因素分析显示，Bmi-1表达是HCC患者的一个显著和独立的预后参数（P = 0.002.Conclusion我们的研究表明，Bmi-1可能是HCC长期生存的候选生物标志物。
Purpose Recent studies have identified polycomb-group gene Bmi-1 as oncogene in the generation of mouse pre-cell lymphomas, and overexpression of Bmi-1 has been found in several human tumor with the disease progress and poor prognosis of the cancer patients.Methods In present study, we investigated Bmi-1 expression and its prognostic significance in hepatocellular carcinoma (HCC) by performing immunohistochemical analysis, using a total of 137 HCC clinical tissue samples.Results High Bmi-1 expression (Bmi-1 2+ or 3+) was shown in 29.9% cases. The positive immuno-staining of Bmi-1 was not only in well/moderately-differentiated tumor cells, but also in surrounding noncancerous or cirrhotic liver tissue. Bmi-1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the high-Bmi-1 group had a significantly shorter overall survival time than the low-Bmi-1 group (P = 0.047). Multivariate analysis after 24 months revealed that Bmi-1 expression was a significant and independent prognostic parameter (P = 0.002) for HCC patients.Conclusion Our study indicated that Bmi-1 could be a candidate biomarker for long-term survival in HCC.