Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours
Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours
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DOI：
10.1002/path.1019
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发表时间：
2002-02-01
影响因子：
7.3
通讯作者：
Chu, AC
中科院分区：
文献类型：
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作者：
Papadavid, E;Pignatelli, M;Chu, AC
E-cadherin/catenin （α -， β -和γ -）复合物在上皮分化的控制中起关键作用。本研究的目的是检测e -钙粘蛋白和α -、β -和γ -连环蛋白在癌前和恶性非黑素细胞皮肤肿瘤（NMST）中的免疫反应性，并通过建立的组织病理学标准和Ki-67指数来评估它们的表达与肿瘤分化程度的相关性。对良性nmst也进行了研究。为了研究免疫抑制对E-cadherin和连环蛋白表达的可能影响，该研究比较了肾移植受者（RTRs）和免疫正常患者的肿瘤。对42例鳞状细胞癌（SCCs）（26例来自RTRs， 16例来自非RTRs）、30例Bowen病（11例来自RTRs， 19例来自非RTRs）、11例来自RTRs的非典型鳞状增生性病变、19例来自RTRs的光化性角化病（9例来自RTRs， 10例来自非RTRs）和20例来自RTRs的病毒性疣进行E-cadherin和α -、β -和γ -catenins的免疫过氧化物酶染色。本研究的结果如下。首先，E-cadherin和α -、β -和γ -catenins的异常表达概率从良性到恶性前和恶性NMSTs增加(p
E-cadherin/catenin (alpha-, beta-, and gamma-) complex plays a critical role in the control of epithelial differentiation. The aim of this study was to examine the immunoreactivity of E-cadherin and alpha-, beta-, and gamma-catenins in premalignant and malignant non-melanocytic skin tumours (NMST) and to correlate their expression with the grade of tumour differentiation, as assessed by the established histopathological criteria and by the Ki-67 index. Benign NMSTs were also studied. To investigate any possible influence of immunosuppression in the expression of E-cadherin and catenins, the study compared tumours obtained from renal transplant recipients (RTRs) and immunocompetent patients. Immunoperoxidase staining of E-cadherin and alpha-, beta-, and gamma-catenins was performed in 42 squamous cell carcinomas (SCCs) (26 from RTRs and 16 from non-RTRs), 30 lesions of Bowen's disease (11 from RTRs and 19 from non-RTRs), 11 atypical squamoproliferative lesions from RTRs, 19 actinic keratoses (9 from RTRs and 10 from non-RTRs), and 20 viral warts from RTRs. The findings of this study were as follows. Firstly, the probability of abnormal expression of E-cadherin and alpha-, beta-, and gamma-catenins increased from benign to premalignant and malignant NMSTs (p