The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery
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DOI：
10.1042/bj20050211
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发表时间：
2005-07-01
影响因子：
4.1
通讯作者：
Hübscher, U
中科院分区：
文献类型：
--
作者：
Smirnova, E;Toueille, M;Hübscher, U
人类检查点传感器和交替的夹子Rad9-Rad1-Hus1可以与DNA连接酶I相互作用并特异性地刺激DNA连接酶I。最近报道的Rad9-Rad1-Hus1与MutY DNA糖基酶、DNA聚合酶β和翻盖内切酶I的相互作用现在完善了我们的观点，即长斑块碱基切除机制是Rad9-Rad1-Hus1复合体的重要靶点，从而加强了DNA的质量控制。
The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease I now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.