Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract.
Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract.
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DOI：
10.2147/jir.s282809
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发表时间：
2020
影响因子：
4.5
通讯作者：
Jiang JJ
中科院分区：
文献类型：
--
作者：
Liu D;Qian T;Sun S;Jiang JJ
The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders.
流动性果汁和气道的微生物学细胞，脂质巨噬细胞和倒流食管炎的微生物学。
影响因子：
5.8
作者：
Chang AB;Cox NC;Purcell J;Marchant JM;Lewindon PJ;Cleghorn GJ;Ee LC;Withers GD;Patrick MK;Faoagali J
通讯作者：
Faoagali J