Investigation of anthropometric, biochemical and dietary parameters of obese children with and without non-alcoholic fatty liver disease
Investigation of anthropometric, biochemical and dietary parameters of obese children with and without non-alcoholic fatty liver disease
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DOI：
10.1016/j.appet.2012.09.006
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发表时间：
2012-12-01
期刊：
影响因子：
5.4
通讯作者：
Rousso, Israel
中科院分区：
文献类型：
--
作者：
Papandreou, Dimitrios;Karabouta, Zaharoula;Rousso, Israel
儿童非酒精性脂肪性肝病（NAFLD）已被认为是一种主要的健康负担。NAFLD的高患病率可能是由于当代流行的肥胖、不健康的饮食模式和久坐的生活方式。本研究的目的是调查希腊肥胖儿童与非NAFLD的人体测量，生化和饮食摄入参数。82名8-15岁的肥胖儿童（45名男孩/37名女孩）参加了这项研究。超声检查（US）被用来诊断NAFLD在所有参与的主题。所有儿童均测量肝脏指数。记录所有受试者的3天饮食。连续变量的数据表示为平均值+/-标准差。82例受试者中有35例（42.6%）患有NAFLD。体重指数水平（P < 0.001）和腰围重度NAFLD患儿血清TNF-α水平显著高于对照组（P < 0.046）（37.2 kg/m2 +/- 6.2和102.9 cm +/- 14）与轻度NAFLD儿童相比（26.6 kg/m2 +/- 3.3和86.1 cm +/- 9.9）和无脂肪肝（25.3 kg/m2 +/- 3.6和85.2 cm +/- 11.2）。NAFLD受试者的总碳水化合物摄入量（288.8 g +/- 70.6）显著高于非NAFLD儿童（244.5 g +/- 67.5）（P < 0.001）。饱和脂肪酸（SFA）的摄入量与肝脏脂肪变性的程度成比例增加，而n-3脂肪酸（n-3 FA）的摄入量与NAFLD呈负相关。多因素回归分析显示，HOMA-IR（OR：1.260，95%CI：1.110-1.470，P < 0.001）和n-3FA（OR：1.921，95%CI：1.132-2.187，P < 0.001）与NAFLD的发病相关。我们的研究结果表明，IR，高膳食摄入的CHO和SFA和低膳食纤维和n-3 FA的消费量与NAFLD的发病正相关。(C)2012爱思唯尔有限公司保留所有权利。
Non-alcoholic fatty liver disease (NAFLD) in children has been recognized as a major health burden. The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity, unhealthy dietary pattern, and sedentary lifestyle. The purpose of this study was to investigate anthropometric, biochemical and dietary intake parameters of obese Greek children with and without NAFLD. Eighty two obese children aged 8-15(45 boys/37 girls) participated in the study. Ultrasonography (US) was used to diagnose NAFLD in all participated subjects. Liver indexes were measured in all children. A 3-day dietary was recorded for all subjects. Data for continuous variables is expressed as mean values +/- standard deviation. Thirty-five out of eighty two subjects (42.6%) had NAFLD. Body Mass Index levels (P < 0.001) and Waist Circumference (P < 0.046) levels were statistically higher in the children with severe NAFLD (37.2 kg/m(2) +/- 6.2 and 102.9 cm +/- 14) compared to children with mild NAFLD (26.6 kg/m(2) +/- 3.3 and 86.1 cm +/- 9.9) and absent of fatty liver (25.3 kg/m(2) +/- 3.6 and 85.2 cm +/- 11.2), respectively. Total carbohydrates intakes were significantly higher in subjects with NAFLD (288.8 g +/- 70.6) compared to children without NAFLD (244.5 g +/- 67.5), (P < 0.001). Saturated fatty acids (SFAs) intake was proportionally increased to the degree of hepatic steatosis, while n-3 fatty acids (n-3 FA) consumption was inversely related with NAFLD. In multiple regression analysis of factors associated with NAFLD, HOMA-IR (OR: 1.260, 95% CI: 1.110-1.470, P < 0.001) and n-3FA (OR:1.921, 95%CI:1.132-2.187, P < 0.001) were the most significant ones. Our results showed that IR, high dietary intakes of CHO and SFA and a low dietary consumption of fiber and n-3 FA were positively associated with the pathogenesis of NAFLD. (C) 2012 Elsevier Ltd. All rights reserved.