DIFFERENTIAL INVOLVEMENT OF GUSTATORY INSULAR CORTEX AND AMYGDALA IN THE ACQUISITION AND RETRIEVAL OF CONDITIONED TASTE-AVERSION IN RATS
DIFFERENTIAL INVOLVEMENT OF GUSTATORY INSULAR CORTEX AND AMYGDALA IN THE ACQUISITION AND RETRIEVAL OF CONDITIONED TASTE-AVERSION IN RATS
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DOI：
10.1016/s0166-4328(05)80328-6
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发表时间：
1992-11-30
影响因子：
2.7
通讯作者：
BURES, J
中科院分区：
文献类型：
--
作者：
GALLO, M;ROLDAN, G;BURES, J
味觉岛叶皮层（GC）和杏仁核（Am）在条件性味觉厌恶（CTA）中作用的损伤研究受到干预不可逆性的混淆。功能性消融方法允许更具体地影响CTA采集和检索的不同阶段。在长期植入脑内插管的大鼠中，在糖精饮用之前或之后，双侧河豚毒素（TTX）阻断GC（10 ng）或Am（3 ng）表明，GC对于味觉刺激的初始处理是必不可少的，但对于味觉痕迹与LiCl中毒症状的关联不是必需的。味觉信号可以绕过被阻断的Am，然而，Am的失活损害了味觉痕迹-中毒关联。TTX注射到GC和Am两者中损害CTA恢复比单独阻断这些结构中的任一个更大。有人认为GC和Am分别实现味觉和内脏信号的处理，但CTA印记的形成和巩固在前脑之外进行，可能在脑干水平。
Lesion studies of the role of the gustatory insular cort" (GC) and amygdala (Am) in conditioned taste aversion (CTA) are confounded by the irreversibility of the intervention. Functional ablation methods allow more specific influencing of different phases of CTA acquisition and retrieval. Bilateral tetrodotoxin (TTX) blockade of GC (10 ng) or Am (3 ng) before or after saccharin drinking in rats with chronically implanted intracerebral cannulae showed that GC is indispensable for the initial processing of the taste stimulus but not for the association of the gustatory trace with the symptoms of LiCl poisoning. Gustatory signals can by-pass the blocked Am, the inactivation of which, however, impairs the gustatory trace-poisoning association. TTX injection into both GC and Am impairs CTA retrieval more than isolated blockade of either of these structures. It is argued that GC and Am implement processing of gustatory and visceral signals, respectively, but that formation and consolidation of the CTA engram proceeds outside forebrain, probably at the level of the brainstem.