Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat
Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat
复制标题
胆酸和鹅烯酸饲喂对大鼠肝脏胆固醇合成率影响的比较
DOI：
10.1007/bf01072189
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Dietschy
中科院分区：
文献类型：
--
作者：
M. Carrella;J. Dietschy
为了比较胆酸和化学酸抑制肝脏中胆固醇合成的能力，将这两种胆汁酸以不同的量喂给大鼠66小时或6周。在这两种情况下，小肠胆汁酸池发生了显著变化，肝脏胆固醇合成速率受到抑制。然而，与施用相同量的化学酸相比，施用胆酸始终对辛酸盐合成胆固醇的速率或微粒体HMG辅酶a还原酶活性产生更大的抑制作用。此外，无论在高底物浓度下测量胆固醇生成率，即在evmax明显达到的条件下，还是在基本上没有细胞外底物存在的情况下，都存在这种差异。这些发现不支持化学酸溶解胆结石的优势次于其作为肝胆固醇合成抑制剂的更大作用的观点。
To compare the ability of cholic acid and chenic acid to suppress cholesterol synthesis in the liver, these two bile acids were fed in varying amounts to rats for either 66 hr or 6 weeks. In both instances there were significant changes in the bile acid pool in the small intestine and suppression of the rate of cholesterol synthesis in the liver. The administration of cholic acid, however, consistently produced greater suppression of the rate of cholesterol synthesis from octanoate or of microsomal HMG CoA reductase activity than did the administration of a similar amount of chenic acid. Furthermore, this difference was present whether the rates of cholesterogenesis were measured at high-substrate concentrations, ie, under conditions whereVmaxwas apparently achieved, or under circumstances where there was essentially no extracellular substrate present. These findings do not support the view that the superiority of chenic acid for dissolution of gallstones is secondary to its greater effect as an inhibitor of hepatic cholesterol synthesis.