Capping and stabilizing chronic intravascular cannulae.
Capping and stabilizing chronic intravascular cannulae.
复制标题
封盖和稳定慢性血管内插管。
DOI：
10.1152/jappl.1968.24.4.577
复制
发表时间：
1968
影响因子：
3.3
通讯作者：
J. N. Hayward
中科院分区：
文献类型：
--
作者：
M. A. Baker;E. Burrell;J. Penkhus;J. N. Hayward
The USE OF intravenous or intra-arterial cannulae in chronically maintained laboratory animals is common for it is often desirable to obtain blood samples, monitor vascular pressures, or inject substances intravascularly without disturbing an animal. Various techniques for implanting such cannulae have been described(2, 8, 9, 12-14), but we know of no published description of satisfactory methods for capping and permanently securing the distal ends of cannulae outside the animal body. This report describes a method for capping intravascular cannulae and fixing them to a rigid skull platform so that they are protected in unrestrained animals. The caps allow intravascular injections, withdrawal of blood samples, and attachment of lengths of tubing for pressure measurements or injections initiated far from the animal. The skull platform can be placed easily, and it provides a table to which can be attached not only vascular cannulae but also leads from vascular pressure and flow probes, thermocouples or thermistors in the vascular system, and electrodes in the brain. We have used these techniques successfully in monkeys(3, 5), rabbits(l), cats (4), sheep, and dogs.In all of our studies we have used venous cannulae implanted in the right atrium through the external or internal jugular vein and arterial cannulae implanted in the aorta through the common carotid artery or branches of the common or the external carotid. The access to these vessels in the neck is quite simple, and surgical techniques have been described(6, 9, 13). However, our method for capping and stabilizing cannulae can be used for cannulae in any vessel, provided the distal ends can be brought to the head. We have found silicone rubber tubing to be free from clotting(1 l), though other authors have recommended other materials for chronically implanted cannulae
