QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30
QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30
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DOI：
10.1007/s11136-015-1217-y
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发表时间：
2016-03-01
影响因子：
3.5
通讯作者：
Viney, R.
中科院分区：
文献类型：
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作者：
King, M. T.;Costa, D. S. J.;Viney, R.
从癌症特异性生活质量问卷（EORTC QLQ-C30）中导出健康状态分类系统（HSCS），作为多属性实用工具的基础。基于已建立的QLQ-C30领域结构，构建了hsc概念模型。考虑了几个标准来选择hsc的维度和项目子集。专家意见和患者输入告知关键维度的先验选择。通过对汇总数据集的二次分析来评估心理测量标准，该数据集包括来自8个国家的2616名患者的HRQOL和临床数据，以及一系列原发癌症部位、疾病分期和治疗。我们使用验证性因子分析（CFA）来评估概念模型的稳健性和通用性。我们使用Rasch分析评估了项目下限效应（最低分数为75%）、无序项目反应阈值、潜在变量的覆盖率和差异项目函数。我们根据疾病分期和对变化的反应性计算了已知组比较的效应量。79名癌症患者评估了维度内项目的相对重要性。CFA支持概念模型及其在原发性癌症部位的通用性。在考虑了所有标准后，选出了代表10个维度的12个项目：身体功能（活动能力）、角色功能、社交功能、情感功能、疼痛、疲劳、睡眠、食欲、恶心、肠道问题。由QLQ-C30项目创建的hsc被称为EORTC生活质量效用测量核心10维度（qu - c10d）。qu - c10d发展的下一阶段涉及估值研究，目前正在全球范围内计划或进行。
To derive a health state classification system (HSCS) from the cancer-specific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a multi-attribute utility instrument.The conceptual model for the HSCS was based on the established domain structure of the QLQ-C30. Several criteria were considered to select a subset of dimensions and items for the HSCS. Expert opinion and patient input informed a priori selection of key dimensions. Psychometric criteria were assessed via secondary analysis of a pooled dataset comprising HRQOL and clinical data from 2616 patients from eight countries and a range of primary cancer sites, disease stages, and treatments. We used confirmatory factor analysis (CFA) to assess the conceptual model's robustness and generalisability. We assessed item floor effects (> 75 % observations at lowest score), disordered item response thresholds, coverage of the latent variable and differential item function using Rasch analysis. We calculated effect sizes for known group comparisons based on disease stage and responsiveness to change. Seventy-nine cancer patients assessed the relative importance of items within dimensions.CFA supported the conceptual model and its generalisability across primary cancer sites. After considering all criteria, 12 items were selected representing 10 dimensions: physical functioning (mobility), role functioning, social functioning, emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems.The HSCS created from QLQ-C30 items is known as the EORTC Quality of Life Utility Measure-Core 10 dimensions (QLU-C10D). The next phase of the QLU-C10D's development involves valuation studies, currently planned or being conducted across the globe.