Torque-actuated valves for microfluidics
Torque-actuated valves for microfluidics
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DOI：
10.1021/ac048303p
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发表时间：
2005-08-01
影响因子：
7.4
通讯作者：
Whitesides, GM
中科院分区：
文献类型：
--
作者：
Weibel, DB;Kruithof, M;Whitesides, GM
本文描述了用于控制微流控通道中流体流动的扭矩驱动阀。这些阀门由嵌入聚二甲基硅氧烷(PDMS)制造的微流体通道上方的一层聚亚安酯的小型机械螺丝(>；=500微米)组成。用适当的螺丝进行光化学固化；固化时，它与PDMS的周围层粘合在一起，形成一层坚硬的层，保留螺丝螺纹的印记。通过一层PDMS将阀门与微流控通道的天花板隔开，并使用与软光刻和快速成型兼容的简单程序将其集成到通道中。旋转螺丝通过折叠阀门和通道之间的PDMS层来启动阀门，控制底层通道中的流体流动。这些阀门具有一个有用的特性，即它们不需要电源来保持其设置(开/关)。它们还允许在“开”和“关”之间进行设置，并可以集成到便携式、一次性微流控设备中，以进行三明治免疫分析。
This paper describes torque-actuated valves for controlling the flow of fluids in microfluidic channels. The valves consist of small machine screws (>= 500 mu m) embedded in a layer of polyurethane cast above microfluidic channels fabricated in poly(dimethylsiloxane) (PDMS). The polyurethane is cured photochemically with the screws in place; on curing, it bonds to the surrounding layer of PDMS and forms a stiff layer that retains an impression of the threads of the screws. The valves were separated from the ceiling of microfluidic channels by a layer of PDMS and were integrated into channels using a simple procedure compatible with soft lithography and rapid prototyping. Turning the screws actuated the valves by collapsing the PDMS layer between the valve and channel, controlling the flow of fluids in the underlying channels. These valves have the useful characteristic that they do not require power to retain their setting (on/off). They also allow settings between "on" and "off" and can be integrated into portable, disposable microfluidic devices for carrying out sandwich immunoassays.