Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels
Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels
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DOI：
10.3945/ajcn.2008.26546
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发表时间：
2008-11-01
影响因子：
7.1
通讯作者：
Towne, Bradford
中科院分区：
文献类型：
--
作者：
Demerath, Ellen W.;Reed, Derek;Towne, Bradford
背景资料：尽管认识到中心性肥胖在慢性疾病中起着关键作用，但很少有大规模的成像研究记录了人类腹部脂肪组织模式的变化。目的：我们旨在比较腹部皮下脂肪组织（ASAT）和腹部内脏组织（VAT）与代谢综合征的存在之间的关系，ASAT和VAT在腹部不同位置测量（MS;国家胆固醇教育计划成人治疗小组III定义）和个体心脏代谢危险因素设计：该研究包括713名年龄在18-86岁的非西班牙裔白人，其中通过使用多图像磁共振成像评估VAT和ASAT。包含每个受试者最大增值税区域的磁共振图像的解剖位置被用作增值税图案的测量。多变量线性和Logistic回归分析被用来研究增值税，ASAT，增值税模式的关系，心脏metabolic risk.Results：增值税质量是一个更强的预测MS比ASAT质量，但ASAT质量（和其他措施的皮下肥胖）有显着的相互作用与增值税质量，从而提高ASAT降低了MS的概率高增值税的男性（P = 0.0008）。在男性中，VAT区域与MS的相关性在图像位置之间存在差异，并且位于L4-L5上方4-8 cm的磁共振图像提供了VAT区域与心脏代谢风险因素之间的最强相关性。受试者的最大增值税面积较高，在腹部有较高的LDL-胆固醇浓度（R-2 = 0.07，P < 0.0001），独立的年龄和adiposity.Conclusion：需要进一步的研究，以确认增值税模式对心脏代谢风险的影响。美国临床营养杂志2008; 88：1263-71。
Background: Despite the recognition that central obesity plays a critical role in chronic disease, few large-scale imaging studies have documented human variation in abdominal adipose tissue patterning.Objective: We aimed to compare the associations between abdominal subcutaneous adipose tissue (ASAT) and visceral abdominal tissue (VAT), which were measured at different locations across the abdomen, and the presence of the metabolic syndrome (MS; National Cholesterol Education Program Adult Treatment Panel III definition) and individual cardiometabolic risk factors.Design: This study included 713 non-Hispanic whites aged 18-86 y, in whom VAT and ASAT were assessed by using multiple-image magnetic resonance imaging. The anatomical position of the magnetic resonance image containing the maximum VAT area for each subject was used as a measure of VAT patterning. Multivariate linear and logistic regression analyses were used to examine the relation of VAT, ASAT, and VAT patterning to cardiometabolic risk.Results: VAT mass was a stronger predictor of the MS than was ASAT mass, but ASAT mass (and other measures of subcutaneous adiposity) had signification interactions with VAT mass, whereby elevated ASAT reduced the probability of MS among men with high VAT(P = 0.0008). There was variation across image locations in the association of VAT area with the MS in men, and magnetic resonance images located 4-8 cm above L4-L5 provided the strongest correlations between VAT area and cardiometabolic risk factors. Subjects whose maximum VAT area was higher in the abdomen had higher LDL-cholesterol concentrations (R-2 = 0.07, P < 0.0001), independent of age and adiposity.Conclusion: Further studies are needed to confirm the effects of VAT patterning on cardiometabolic risk. Am J Clin Nutr 2008; 88: 1263-71.