Carbosulfenylation of Alkenes with Organozinc Reagents and Dimethyl(methylthio)sulfonium Trifluoromethanesulfonate
Carbosulfenylation of Alkenes with Organozinc Reagents and Dimethyl(methylthio)sulfonium Trifluoromethanesulfonate
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有机锌试剂和三氟甲磺酸二甲基（甲硫基）锍对烯烃进行硫磺酰基化
DOI：
10.1021/acs.orglett.0c03810
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Lan-Gui Xie
中科院分区：
文献类型：
--
作者：
Meizhong Tang;Shuxiong Han;Shenglan Huang;Shenlin Huang;Lan-Gui Xie
由二甲硫基硫酸盐引发的烯烃的亲电硫醇化反应，以及随后的各种杂核亲核试剂的加入，已经得到了很好的证实。然而，关于碳亲核试剂的使用，只成功地应用了精心设计的sp型碳源。在此，我们介绍了我们的研究结果，即在有机锌试剂的存在下，烯烃与二甲硫基三氟甲磺酸的甲硫醇化反应，然后形成碳-碳键，从而实现了一种无催化剂的烯烃碳磺化反应方案。
The electrophilic alkylthiolation of alkenes, initiated by dimethyl(methylthio)sulfonium salts and the subsequent addition of various heteronucleophilies has been well-established. Regarding the use of carbon nucleophiles, however, only carefully designed sp-type carbon sources have been successfully applied. We herein present our findings on the methylthiolation of alkenes with dimethyl(methylthio)sulfonium trifluoromethanesulfonate, followed by carbon–carbon bond formation in the presence of organozinc reagents, thus achieving a catalyst-free protocol toward to the carbosulfenylation of alkenes.