State dependent changes in error monitoring in schizophrenia
State dependent changes in error monitoring in schizophrenia
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DOI：
10.1016/j.jpsychires.2003.11.002
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发表时间：
2004-05-01
影响因子：
4.8
通讯作者：
Ngan, ETC
中科院分区：
文献类型：
--
作者：
Bates, AT;Liddle, PF;Ngan, ETC
本研究的目的是确定是否错误负性/错误相关负性（N-e/ERN），错误正性（P-e），正确反应负性（CRN）或正确反应正性（P-c）幅度的影响精神分裂症的状态变化。事件相关电位（ERPs）记录从9名精神分裂症患者，而他们进行了一个简单的去/不去的任务，在急性发作的早期阶段，并再次经过6周的抗精神病药物治疗。9名健康参与者在执行相同任务时也记录了ERP。响应锁定电位计算错误的委员会和正确的反应。采用精神病症状和体征量表（SSPI）对精神分裂症患者治疗前后的现实扭曲综合征、精神贫困综合征和组织混乱综合征进行评分。精神分裂症患者急性期N-e/ERN波幅较健康对照组显著降低，治疗后显著升高。精神分裂症患者治疗后Ne/ERN波幅仍显著高于健康组。本研究提示，精神分裂症患者的临床状态对N-e/ERN和CRN振幅有调节作用，进一步支持了N-e/ERN振幅降低是精神分裂症的一个潜在的有用的特质标记，而P-c和P-e振幅并不异常。(C)2003 Elsevier Ltd.保留所有权利。
The aim of this study was to determine if error negativity/error-related negativity (N-e/ERN), error positivity (P-e), correct response negativity (CRN) or correct response positivity (P-c) amplitude are influenced by state changes in schizophrenia. Event-related potentials (ERPs) were recorded from nine schizophrenic patients while they performed a simple go/no-go task during the early stages of an acute episode and again following 6 weeks of treatment with antipsychotics. ERPs were also recorded from nine healthy participants while they performed the same task. Response-locked potentials were computed for errors of commission and for correct responses. Scores for reality distortion syndrome, psychomotor poverty syndrome and disorganization syndrome were determined for the schizophrenic participants before and after treatment using the Signs and Symptoms of Psychotic Illness (SSPI) Scale. N-e/ERN amplitude was significantly reduced, compared with that in healthy participants, in the schizophrenic patients when acutely ill, and increased significantly following treatment. Ne/ERN amplitude remained significantly larger in the healthy group than in the patients with schizophrenia after treatment. This study suggests that N-e/ERN and CRN amplitude are modulated by clinical state in schizophrenia and provides further support to findings that decreased N-e/ERN amplitude is a potentially useful trait marker for schizophrenia, while P-c and P-e amplitude are not abnormal. (C) 2003 Elsevier Ltd. All rights reserved.