Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients
Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients
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Tiam1在肝细胞癌中的过度表达预示着HCC患者的不良预后
DOI：
10.1002/ijc.23954
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发表时间：
2009-02-01
影响因子：
6.4
通讯作者：
Luo, Rongcheng
中科院分区：
文献类型：
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作者：
Ding, Yi;Chen, Bin;Luo, Rongcheng
很少有研究测试 T 淋巴瘤侵袭和转移 1 (Tiam1) 作为肝细胞癌 (HCC) 预后标志物的有效性。在本研究中，我们研究了 Tiam1 表达及其对 HCC 的预后价值。 HCC 手术组织样本取自 152 名经过 5 年随访的 HCC 患者。 63.8% 的病例显示 Tiam1 过度表达（Tiam1 2+ 至 3+）。 Tiam1 表达水平与任何临床病理参数均不相关。然而，生存分析显示Tiam1过表达组的总生存时间显着短于Tiam1下调表达组（p = 0.008）。多变量分析表明，Tiam1 表达是 HCC 患者的一个显着且独立的预后参数 (p = 0.042)。 Tiam1 表达可能是 HCC 患者预后的新型独立预测因子。 (C) 2008 Wiley-Liss, Inc.
Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression and its prognostic value for HCC. HCC surgical tissue samples were taken from 152 HCC patients who had been followed up for 5 years. Overexpression of Tiam1 (Tiam1 2+ to 3+) was shown in 63.8% of the cases. The Tiam1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the Tiam1 overexpression group had a significantly shorter overall survival time than the Tiam1 downexpression group (p = 0.008). Multivariate analysis showed that Tiam1 expression was a significant and independent prognostic parameter (p = 0.042) for HCC patients. Tiam1 expression may be a novel and independent predictor for the prognosis of HCC patients. (C) 2008 Wiley-Liss, Inc.