Prenatal thalamic waves regulate cortical area size prior to sensory processing.
Prenatal thalamic waves regulate cortical area size prior to sensory processing.
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DOI：
10.1038/ncomms14172
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发表时间：
2017-02-03
影响因子：
16.6
通讯作者：
López-Bendito G
中科院分区：
文献类型：
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作者：
Moreno-Juan V;Filipchuk A;Antón-Bolaños N;Mezzera C;Gezelius H;Andrés B;Rodríguez-Malmierca L;Susín R;Schaad O;Iwasato T;Schüle R;Rutlin M;Nelson S;Ducret S;Valdeolmillos M;Rijli FM;López-Bendito G
大脑皮层被组织成专门的感觉区域，其初始区域由皮质内分子决定。然而，感觉皮质面积的大小似乎在发育过程中被微调以响应功能适应。在这里，我们证明了存在一种产前皮层下机制来调节小鼠皮层区域的大小。这种机制是由自发的丘脑钙波介导的，这些钙波在丘脑感觉核之间向上传播到皮层，并提供了感觉系统之间的通信手段。一个核的波形改变会导致其他核的波形改变，从而引发丘脑基因表达和皮层面积大小的变化。因此，听觉丘脑中的沉默钙波诱导邻近体感核中的Rorβ上调，从而阻止了桶区扩大。这些发现表明胚胎丘脑钙波在感觉信息加工之前协调皮层感觉区模式和可塑性。感官地图是如何在大脑中形成的，目前还不完全清楚。在这里，作者描述了在胚胎丘脑的不同感觉核中传播的自发钙波；破坏脑电波模式会引发丘脑基因表达的变化，最终改变皮层区域的大小。
The cerebral cortex is organized into specialized sensory areas, whose initial territory is determined by intracortical molecular determinants. Yet, sensory cortical area size appears to be fine tuned during development to respond to functional adaptations. Here we demonstrate the existence of a prenatal sub-cortical mechanism that regulates the cortical areas size in mice. This mechanism is mediated by spontaneous thalamic calcium waves that propagate among sensory-modality thalamic nuclei up to the cortex and that provide a means of communication among sensory systems. Wave pattern alterations in one nucleus lead to changes in the pattern of the remaining ones, triggering changes in thalamic gene expression and cortical area size. Thus, silencing calcium waves in the auditory thalamus induces Rorβ upregulation in a neighbouring somatosensory nucleus preluding the enlargement of the barrel-field. These findings reveal that embryonic thalamic calcium waves coordinate cortical sensory area patterning and plasticity prior to sensory information processing. How sensory maps are formed in the brain is only partially understood. Here the authors describe spontaneous calcium waves that propagate across different sensory nuclei in the embryonic thalamus; disrupting the wave pattern triggers thalamic gene expression changes and eventually alters the size of cortical areas.