Absence of Asymptomatic Malaria Infections in Previously High Endemic Areas of Sri Lanka
Absence of Asymptomatic Malaria Infections in Previously High Endemic Areas of Sri Lanka
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DOI：
10.4269/ajtmh.2009.09-0042
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发表时间：
2009-11-01
影响因子：
3.3
通讯作者：
Rajapaksa, Lalani C.
中科院分区：
文献类型：
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作者：
Fernando, S. Deepika;Abeyasinghe, Rabindra R.;Rajapaksa, Lalani C.
由于目前正在实现在斯里兰卡消除疟疾的目标，计划进行这项研究以确定无症状疟疾感染的流行率。在亭可马里和库鲁内加拉地区，有针对性地选择了最近报告发病率较高的五个卫生区。确定了每个地区内疟疾风险较高的最小行政单位(GN区)。从这些分区中，随机选择了20%的人群进行血液涂片检查，并在50%的亚样本中进行了聚合酶链式反应(PCR)分析。从13个GN分区抽样调查了3730人。Giemsa染色的厚薄血液涂片对疟疾寄生虫的检测均为阴性。在50%的研究样本中进行的聚合酶链式反应也是疟疾寄生虫阴性。调查结果表明，在以前的高传播区没有无症状携带者，似乎到2015年在斯里兰卡实现消除疟疾是可行的。
As the goal of malaria elimination from Sri Lanka is currently being pursued, this study was planned to determine the prevalence of asymptomatic malaria infections. Five health areas in Trincomalee and Kurunegala districts that reported high prevalence in the recent past Were purposively selected. The smallest administrative units (GN divisions) having high malaria risk within each area were identified. From these divisions, 20% of the population was randomly selected for blood smear examination and in a 50% sub-sample polymerase chain reaction (PCR) assay was performed. A population of 3,730 from 13 GN divisions was sampled. Thick and thin Giemsa-stained blood smears were negative for malaria parasites. The PCR carried out in 50% of the study sample was also negative for malaria parasites. The findings illustrate the absence of asymptomatic carriers in previously high transmission areas and it appears that achieving malaria elimination in Sri Lanka by 2015 is feasible.