IMMUNOGLOBULIN RESPONSES IN ACUTE Q-FEVER
IMMUNOGLOBULIN RESPONSES IN ACUTE Q-FEVER
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DOI：
10.1128/jcm.22.4.484-487.1985
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发表时间：
1985-01-01
影响因子：
9.4
通讯作者：
HALLER, E
中科院分区：
文献类型：
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作者：
DUPUIS, G;PETER, O;HALLER, E
了解急性Q热病程中不同类别抗体的变化情况，对于临床医生解读患者S的血清学检测结果具有重要意义。在本研究中，检测了为期一年的伯氏柯克斯体I期和II期抗体的出现。对191例Q热患者的683份血清进行了补体结合试验和间接免疫荧光试验(免疫球蛋白M和G[IgM，IgG])检测。这些患者在1983年秋天的一次流行期间患上了急性Q热，导致415例血清学确诊的Q热病例。补体结合试验表明，在整个研究期间，伯氏梭菌II期抗体一直升高，而I期抗体几乎检测不到。虽然免疫荧光试验比补体结合试验更敏感，但对伯氏梭菌I期和II期的特异性抗-Ig G反应与补体结合试验提供了相同的一般抗体谱。免疫球蛋白抗体I、II滴度出现较早，10~12周后消失。在此期间，抗II期抗体水平普遍远高于抗I期抗体水平。
Knowledge of the development of different classes of antibody during the course of acute Q fever is important to the clinician for interpreting a patient''s serological test results. In the present study, the appearance of antibodies to Coxiella burnetii phases I and II was determined for a period of 1 year. A total of 683 sera from 191 patients with symptomatic Q fever were evaluated by the complement fixation and indirect immunofluorescence (immunoglobulins M and G [IgM, IgG]) tests. These patients had contracted acute Q fever in the fall of 1983 during an epidemic that resulted in 415 serologically confirmed cases of Q fever. As demonstrated by the complement fixation test, antibodies to C. burnetii phase II remained elevated throughout the entire study period, whereas antibodies to phase I were barely detectable. Although the immunofluorescence test was more sensitive than the complement fixation test, the specific anti-IgG response to C. burnetii to phases I and II gave the same general antibody profiles as did the complement fixation test. IgM anti-hase I and II titers appeared earlier but disappeared after 10 to 12 weeks. During this period, anti-phase II antibody levels were generally much higher than anti-phase I antibody levels.