HIGHER SENSITIVITY OF LEC STRAIN RAT IN RADIATION-INDUCED ACUTE INTESTINAL DEATH
HIGHER SENSITIVITY OF LEC STRAIN RAT IN RADIATION-INDUCED ACUTE INTESTINAL DEATH
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DOI：
10.1292/jvms.54.269
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发表时间：
1992-04-01
影响因子：
1.2
通讯作者：
NAMIOKA, S
中科院分区：
文献类型：
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作者：
HAYASHI, M;ENDOH, D;NAMIOKA, S
LEC品系大鼠(LEC大鼠)出生后4-5个月发生遗传性自发性暴发性肝炎，与WKAH品系大鼠(WKAH大鼠)相比，LEC品系大鼠对全身X射线照射高度敏感。剂量高于6.5Gy时，LEC大鼠发生放射性急性肠死亡。WKAH大鼠剂量分别高于12.8Gy.生存数据的概率分析表明，LEC大鼠的LD50/7为7.03Gy值，显著低于WKAH大鼠的LD50/7值(12.99Gy.8.5Gy线照射后2d，LEC大鼠小肠组织病理学检查显示肠上皮细胞严重死亡并伴有水肿，而8.5Gy线照射WKAH组大鼠肠上皮细胞几乎无明显变化。这些结果提示LEC大鼠对电离辐射的敏感性高于其他品系的大鼠。
LEC strain rats (LEC rats), which have been known to develop hereditarily spontaneous fulminant hepatitis 4-5 months after birth, were highly sensitive to whole-body X-irradiation as compared to WKAH strain rats (WKAH rats). Radiation-induced acute intestinal death occurred at doses higher than 6.5 Gy in LEC rats. and at doses higher than 12.8 Gy in WKAH rats, respectively. By the probit analysis of survival data, it was shown that the LD50/7 value of LEC rats was estimated to be 7.03 Gy which was significantly lower than that (12.99 Gy) of WKAH rats. Histopathological examinations of small intestines from LEC rats 2 days after irradiation at the dose of 8.5 Gy showed severe epithelial death together with edema, whereas little or no significant changes were noted in intestinal epithelium of 8.5 Gy-irradiated WKAH rats. These results suggest that the radiosensitivity of LEC rats to ionizing radiation appears to be higher than that of other strains of rats.