What, If Anything, Is Rodent Prefrontal Cortex?
What, If Anything, Is Rodent Prefrontal Cortex?
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DOI：
10.1523/eneuro.0315-18.2018
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发表时间：
2018-09
期刊：
影响因子：
3.4
通讯作者：
White SR
中科院分区：
文献类型：
--
作者：
Laubach M;Amarante LM;Swanson K;White SR
前额叶皮层（PFC）对不同的人有不同的意义。近年来，关于PFC的出版物有了很大的增加，特别是使用老鼠。然而，PFC区域的命名法和解剖学边界的不一致使得研究人员难以比较数据和解释跨物种的发现。我们对人类和啮齿动物的PFC出版物进行了荟萃分析，发现对这些物种的研究重点存在巨大差异。此外，我们比较了几种常见的啮齿动物脑地图集的解剖学术语和标准，发现了主要地图集之间甚至内部的不一致。为了评估这些问题对研究界的影响，我们对已建立的PFC研究人员进行了一项关于他们使用解剖学术语的调查，发现很少有共识。我们报告了调查结果，并提出了一种基于胼胝体结构分析和灵长类动物前扣带皮层（ACC）研究中使用的命名法来解释啮齿动物研究数据的替代方案。
Prefrontal cortex (PFC) means different things to different people. In recent years, there has been a major increase in publications on the PFC, especially using mice. However, inconsistencies in the nomenclature and anatomical boundaries of PFC areas has made it difficult for researchers to compare data and interpret findings across species. We conducted a meta-analysis of publications on the PFC of humans and rodents and found dramatic differences in the focus of research on these species. In addition, we compared anatomical terms and criteria across several common rodent brain atlases and found inconsistencies among, and even within, leading atlases. To assess the impact of these issues on the research community, we conducted a survey of established PFC researchers on their use of anatomical terms and found little consensus. We report on the results of the survey and propose an alternative scheme for interpreting data from rodent studies, based on structural analysis of the corpus callosum and nomenclature used in research on the anterior cingulate cortex (ACC) of primates.